Skin tumors in photochemotherapy for psoriasis: a single-center follow-up of 496 patients

Dermatology : International Journal for Clinical and Investigative Dermatology
H MaierH Hönigsmann

Abstract

The significance of oral psoralen photochemotherapy (PUVA) for the development of nonmelanoma skin cancers (NMSC) is still controversial. We evaluated 496 psoriatics, who received PUVA treatment according to the European PUVA protocol in order to reassess the influence of the cumulative UVA dose on the development of NMSC and to answer the question if there is a UVA threshold dose above which the carcinogenic risk is increased. The study was conducted as a retrospective investigation. All patients were seen personally. Age, sex, skin type, cumulative UVA dose and carcinogenic risk factors (arsenic, X-rays, tar, UVB, methotrexate) were recorded and investigated by marginal (MA) and partial effects analyses (PA) according to the Cox regression model. In 14 patients (2.8%), one or multiple histologically confirmed NMSC were diagnosed. Nine patients (1.8%) had squamous cell carcinoma (SCC), 5 patients (1.0%) had basal cell carcinoma (BCC). No patient had both types of NMSC. None of the SCC had metastasized. By taking the appearance of BCC and SCC as the endpoint, arsenic [MA: relative risk (RR) = 7.62; PA:RR = 5.36], tar (MA:RR = 4.51; PA:RR = 3.83) and methotrexate (MTX; MA:RR = 4.97; PA:RR = 4.07) appear to produce strong and sig...Continue Reading

Citations

Apr 26, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·G Hofbauer
Dec 4, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lutz BräutigamGerd Geisslinger
Dec 31, 2003·Journal of the American Academy of Dermatology·Maritza A Middelkamp-HupSalvador González
Aug 25, 1999·Journal of the American Academy of Dermatology·A TanewH Hönigsmann
Mar 4, 2000·Clinics in Dermatology·E Nicolaidou, A D Katsambas
Jul 27, 1999·The British Journal of Dermatology·B LindelöfL Emtestam
Jul 18, 2002·The Australasian Journal of Dermatology·Nghi T HuynhChristopher A Commens
Feb 1, 2003·Pediatric Dermatology·Aida PasićDamir Hrsan
Apr 10, 1997·The New England Journal of Medicine·K Wolff
Nov 26, 2013·The Cancer Journal·Sabine Hensler, Margareta M Mueller
Feb 12, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Malgorzata Zak-PrelichAnna Sysa-Jedrzejowska
May 13, 1999·Photodermatology, Photoimmunology & Photomedicine·K FaguerD Leroy
Jul 27, 1999·Environmental Health Perspectives·M CölS Oztürk
May 20, 1998·Journal of the American Academy of Dermatology·P Calzavara-Pinton
Jul 26, 2003·The Journal of Investigative Dermatology·Tamar E C Nijsten, Robert S Stern
May 5, 2005·International Journal of Dermatology·Ernest LeeTim Berger
Sep 24, 2004·Dermatologic Therapy·Debra Lewkowicz, Alice B Gottlieb
May 26, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·E ArchierM-A Richard
Nov 4, 2004·Journal of the American Academy of Dermatology·Franz J LegatPeter Wolf
Mar 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Margareta M Mueller
Mar 5, 1998·Journal of the American Academy of Dermatology·H TakedaS Kondo
May 20, 1998·Dermatologic Clinics·K Momtaz, T B Fitzpatrick
Aug 15, 1998·Dermatologic Clinics·R Howard, A Tsuchiya

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