Skin wound trauma, following high-dose radiation exposure, amplifies and prolongs skeletal tissue loss

Bone
Joshua M SwiftMatthew R Allen

Abstract

The present study investigated the detrimental effects of non-lethal, high-dose (whole body) γ-irradiation on bone, and the impact that radiation combined with skin trauma (i.e. combined injury) has on long-term skeletal tissue health. Recovery of bone after an acute dose of radiation (RI; 8 Gy), skin wounding (15-20% of total body skin surface), or combined injury (RI+Wound; CI) was determined 3, 7, 30, and 120 days post-irradiation in female B6D2F1 mice and compared to non-irradiated mice (SHAM) at each time-point. CI mice demonstrated long-term (day 120) elevations in serum TRAP 5b (osteoclast number) and sclerostin (bone formation inhibitor), and suppression of osteocalcin levels through 30 days as compared to SHAM (p<0.05). Radiation-induced reductions in distal femur trabecular bone volume fraction and trabecular number through 120 days post-exposure were significantly greater than non-irradiated mice (p<0.05) and were exacerbated in CI mice by day 30 (p<0.05). Negative alterations in trabecular bone microarchitecture were coupled with extended reductions in cancellous bone formation rate in both RI and CI mice as compared to Sham (p<0.05). Increased osteoclast surface in CI animals was observed for 3 days after irradiati...Continue Reading

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Citations

Dec 14, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jeffrey A Meganck, Bob Liu
Jun 4, 2020·International Journal of Molecular Sciences·Meetha MedhoraBrian L Fish
Aug 17, 2019·Scientific Reports·Youbai ChenCharles E Butler
Jul 8, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Julie GlowackiJoel S Greenberger

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