Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a.

BioFactors
Jing CuiBaisui Feng

Abstract

Baicalein has been widely studied and showed a potent activity against pancreatic cancer in both in vivo and in vitro studies. Little is known regarding the effects of Skullcapflavone I (SFI), despite they have similar structures. So, this study was to explore the function of SFI on human pancreatic cancer. Panc-1 cells were transfected with miR-23a precursor, miR-23a inhibitor or the negative controls, and subsequently treated by SFI. Cell viability, Bromodeoxyuridine (BrdU)-positive cell rate, apoptosis, migration, invasion, and related protein expression were assessed by utilizing Cell Counting Kit-8 (CCK-8), BrdU staining, apoptosis assessment, transwell assay, and western blot. SFI significantly reduced the proliferation, migration, and invasion, as well as induced apoptosis of Panc-1 cells. MiR-23a, miR-21, and miR-155 were lowly expressed while miR-145 and miR-146a were highly expressed in SFI-treated cell. Of note, the antitumor effects of SFI were promoted by miR-23a suppression whereas attenuated by miR-23a overexpression. JAK/STAT and MAPK pathways were inhibited by SFI. Also, the pathway inhibition in SFI-treated cells was reversed by miR-23a overexpression. SFI might be a promising anti-pancreatic cancer agent by i...Continue Reading

References

Feb 1, 1996·Japanese Journal of Cancer Research : Gann·Y MatsuzakiK Okita
Jul 14, 1998·Journal of Biomedical Science·R Garcia, R Jove
Jun 13, 2000·Oncogene·J I Song, J R Grandis
Feb 1, 1996·Cancer Biotherapy & Radiopharmaceuticals·B Y WongC P Wan
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Evropi TheodoratouHarry Campbell
Apr 11, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ge ZhangYinyu Shi
Jul 8, 2011·World Journal of Gastroenterology : WJG·Miroslav ZavoralMarek Minarik
Aug 2, 2012·Pancreas·Ioannis G PapaconstantinouDionysios Voros
Feb 15, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfonso Quintás-Cardama, Srdan Verstovsek
Dec 21, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bailong LiJianming Cai
Jan 23, 2014·JAMA : the Journal of the American Medical Association·Nicolai A SchultzJulia S Johansen
Feb 13, 2014·Oncology Letters·Lin ChengJianwen Gu
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 18, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yu HeShuhua Yang
Feb 24, 2015·Digestive Diseases and Sciences·Ning LiuWei-Neng Fu
Feb 27, 2015·Nature·Nicola WaddellSean M Grimmond
Jun 30, 2015·PloS One·Marine HumeauPierre Cordelier
Jul 21, 2015·Frontiers in Genetics·Yevgeniy GindinPaul S Meltzer
Jan 19, 2018·Kidney Diseases·Federica PetrilloFrancesco Trepiccione
Jan 20, 2018·International Journal of Genomics·Luka BolhaDamjan Glavač
Feb 1, 2018·Cancers·Idoroenyi Amanam, Vincent Chung

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