SLAM: Stereotactic Radiosurgery of Large Arteriovenous Malformations: Meta-analysis of Hemorrhage in High-Grade Pollock-Flickinger Arteriovenous Malformations

World Neurosurgery
Christine Y MauCharles J Prestigiacomo

Abstract

The prognosis of arteriovenous malformations (AVMs) after treatment has been predicted largely by 2 grading scales: the Spetzler-Martin and Pollock-Flickinger. Although there are studies that examine the rate of hemorrhage with the Spetzler-Martin scale, there have not been studies examining hemorrhage in which the Pollock-Flickinger score was used. The annual hemorrhage rate after radiosurgery of Pollock-Flickinger AVM scores >2 is analyzed. Literature search for radiosurgery of large AVMs from January 1, 2000 to June 1, 2014 was conducted. Articles were examined for individual patient data and aggregate patient data that reported hemorrhage rates and mortality. Patients were only included if they had an AVM score ≥2. Annual AVM hemorrhage rate after radiosurgery for all patients (n = 673) was 3.22% (99.3 hemorrhages, 3080.5 follow-up years, 95% confidence interval [95% CI] 2.64%-3.89%). Mortality rate from hemorrhage was 40.08% (95% CI 31.21%-49.90%). A total of 203 patients presented with hemorrhage and 395 did not. In patients with first-time hemorrhage, the annual hemorrhage rate was 3.53% (95% CI 2.66%-4.77%). The annual hemorrhage rate of those with hemorrhagic presentation was 6.10% (95% CI 4.65%-8.07%). The odds ratio ...Continue Reading

References

Jul 12, 1990·The New England Journal of Medicine·G K SteinbergG D Silverberg
Oct 1, 1986·Journal of Neurosurgery·R F Spetzler, N A Martin
Mar 1, 1983·Journal of Neurosurgery·C J GrafJ C Torner
Jan 1, 1996·Stroke; a Journal of Cerebral Circulation·B E PollockD Kondziolka
Jun 1, 1996·Journal of Neurosurgery·W A FriedmanP S Kubilis
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·B KarlssonM Söderman
Jan 17, 2002·Journal of Neurosurgery·Bruce E Pollock, John C Flickinger
May 29, 2004·Stroke; a Journal of Cerebral Circulation·Alexander X HalimWilliam L Young
Jan 14, 2005·The New England Journal of Medicine·Keisuke MaruyamaTakaaki Kirino
Dec 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Angelika Zabel-du BoisJürgen Debus
Dec 30, 2006·Stroke; a Journal of Cerebral Circulation·Mahesh V JayaramanMichael P Marks
Nov 6, 2007·Journal of Neurosurgery·Shigeki YamadaNobuo Hashimoto
Nov 15, 2008·Stroke; a Journal of Cerebral Circulation·Leodante da CostaMichael Tymianski
Apr 23, 2011·Stroke; a Journal of Cerebral Circulation·Chun-Po YenDavid Schlesinger
Nov 10, 2011·JAMA : the Journal of the American Medical Association·Janneke van BeijnumCatharina J M Klijn
Nov 23, 2011·Stereotactic and Functional Neurosurgery·Kwame AmponsahStephen B Tatter
Dec 4, 2012·Journal of Neurosurgery·Bradley A Gross, Rose Du
Jan 1, 2014·British Journal of Neurosurgery·Dale DingJason P Sheehan

❮ Previous
Next ❯

Citations

Dec 19, 2015·World Neurosurgery·Robert Ecker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.