Slamming the DOR on chemokine receptor signaling: heterodimerization silences ligand-occupied CXCR4 and delta-opioid receptors

European Journal of Immunology
Dale Hereld, Tian Jin

Abstract

Dimerization has emerged as a common mechanism for regulating the function of G protein-coupled receptors (GPCR). Among these are chemokine receptors, which detect various chemokines and regulate a range of physiological process, including immune cell trafficking, cancer cell migration, and neuronal patterning. Homo- and heterodimerization in response to chemokine binding has been shown to be required for the initiation or alteration of signaling by a number of chemokine receptors. In this issue of the European Journal of Immunology, a new study indicates that the formation of heterodimers of chemokine receptor CXCR4 and the delta-opioid receptor (DOR) prevents each of them from actively signaling, suggesting a novel mechanism for silencing GPCR function.

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Citations

Dec 23, 2008·Cellular and Molecular Life Sciences : CMLS·C L SalangaT Handel
Sep 13, 2011·Journal of Medicinal Chemistry·Oliver DemmerHorst Kessler
Nov 2, 2013·Cellular and Molecular Life Sciences : CMLS·Mohammad JaberRachel Bar-Shavit
Mar 6, 2009·Current Opinion in Supportive and Palliative Care

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