SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) polymorphisms are associated with end-stage renal disease in diabetic nephropathy

Diabetes
Jae Hyeon KimKyong Soo Park

Abstract

Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD). Genetic susceptibility plays an important role in the development and progression of diabetic nephropathy. Previous studies have revealed that polymorphisms in the SLC12A3 (solute carrier family 12 member [sodium/chloride] 3) gene, which encodes solute carrier family 12 member 3, might contribute to genetic susceptibility to diabetic nephropathy and essential hypertension. In this study, we examined whether the SLC12A3 gene locus is associated with ESRD resulting from diabetic nephropathy. We genotyped 11 common single nucleotide polymorphisms (SNPs) in the SLC12A3 gene in 177 patients with ESRD due to type 2 diabetes and 184 patients with diabetic retinopathy but with no signs of renal involvement. Three SNPs (g.34372G>A [Arg913Gln], g.39143G>A, and g.41727C>T) were found to be associated with ESRD due to diabetic nephropathy. These three SNPs were in complete linkage disequilibrium. Haplotype 4 in block 2 (18806C, 21822C, 34372A, 39143A, 39240T, 39375C, and 41727T) showed a significant association with ESRD due to type 2 diabetes (P = 0.0028). These results suggest that the SLC12A3 gene locus is associated with ESRD due to diabetic nephropathy.

References

Apr 1, 1992·Kidney International·K Borch-JohnsenH H Parving
Jan 16, 2002·American Journal of Human Genetics·Daniel J SchaidGregory A Poland
Mar 12, 2004·Nephrology·Suk Young KimByung Kee Bang
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jun 18, 2005·Genomics·Raymond D MillerUNKNOWN SNP Consortium Allele Frequency Project

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Citations

Mar 23, 2007·Acta Pharmacologica Sinica·Wei-xia ZhangWei-min Cai
Sep 13, 2011·PloS One·Maija WessmanUNKNOWN FinnDiane Study Group
Dec 25, 2012·Yi chuan = Hereditas·Jun-Yan LiHao Lu
Nov 3, 2009·The Journal of Pathology·Amy J McKnightAlexander P Maxwell
Dec 19, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Nadia TabassumDarren R Williams
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Shiro Maeda
Sep 6, 2006·Hypertension·Sara GiuntiMark E Cooper
Apr 27, 2007·Clinical Pharmacology and Therapeutics·S V VormfeldeJ Brockmöller
Feb 12, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel P K NgAndrzej S Krolewski
Jun 15, 2007·Current Opinion in Nephrology and Hypertension
Dec 24, 2018·Kidney Diseases·Ling WeiLin Sun
Jan 10, 2020·Kidney & Blood Pressure Research·Qiuhong BaoHaiyu Jia
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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