SLC19A1 80G allele as a biomarker of methotrexate-related gastrointestinal toxicity in Portuguese rheumatoid arthritis patients

Pharmacogenomics
Aurea LimaRui Medeiros

Abstract

The aim of our study was to characterize the association of clinicopathological variables and the SLC19A1/RFC-1 G80A polymorphism in methotrexate (MTX)-related toxicity in Portuguese patients with rheumatoid arthritis. The study included 233 consecutively recruited patients with rheumatoid arthritis under MTX treatment. The SLC19A1 G80A polymorphism was evaluated by PCR-RFLP. Statistical analysis revealed that SLC19A1 80G carriers had increased risk of gastrointestinal toxicity (odds ratio [OR]: 2.61, p = 0.019) and that regular folic acid supplementation was associated with both overall and gastrointestinal toxicity protection (OR: 0.15, p < 0.001 and OR: 0.19, p < 0.001, respectively). Multivariate analysis confirmed the association of SLC19A1 80G and regular folic acid supplementation to gastrointestinal toxicity (OR: 5.53 and 0.13, respectively). Moreover, a multivariate Cox regression model demonstrated a higher risk of earlier gastrointestinal toxicity in SLC19A1 80G carriers (hazard ratio: 3.63, p = 0.002). SLC19A1 G80A genotyping may be a useful tool for clinicians to identify patients at higher risk for developing gastrointestinal toxicity related to MTX treatment.

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Citations

Nov 27, 2015·Expert Opinion on Drug Metabolism & Toxicology·Maciej TarnowskiAndrzej Pawlik
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Sep 22, 2018·The Pharmacogenomics Journal·Andrea Giletti, Patricia Esperon
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Aug 28, 2020·Journal of Ophthalmology·Ge Wang, Xiaoyan Peng
Jul 9, 2020·Rheumatology·Laura E Dedmon

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Methods Mentioned

BETA
ESR
PCR

Software Mentioned

SPSS

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