SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study

Lupus
H LaustrupP Junker

Abstract

In 1995 all systemic lupus erythematosus (SLE) patients in the county of Funen were retrieved from four separate and independent sources as part of an 8-year prospective study to determine the pattern of disease activity and damage accumulation in a community based lupus cohort of predominantly Scandinavian ancestry. Incident cases were subsequently identified by surveillance of these sources. Established and new cases underwent annual, structured interviews, clinical examination and blood sampling. The Systemic Lupus Erythematosus Diseases Activity Index SLEDAI and Systemic Lupus International Collaborating Clinics SLICC scores were calculated. Flares were defined as modified - SLEDAI >or= 4. The annual flare rate in definite SLE (D-SLE) was 0.21 (95%CI 0.18-0.24) versus 0.03 (95%CI 0.01-0.07) in incomplete SLE (I-SLE). Forty-three per cent of the entire study population had no disease exacerbations. Infections requiring hospital admission and thrombocytopenia were significantly more frequent among patients with relapsing disease (p < 0.04-0.01). Patients with flares had slightly shorter disease duration and were younger at disease onset than patients with a quiescent course. The most recently diagnosed patients had the lowest...Continue Reading

References

Nov 1, 1989·Archives of Internal Medicine·J M Greer, R S Panush
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jan 1, 1997·Lupus·T StollD A Isenberg
Feb 9, 2000·Scandinavian Journal of Rheumatology·C C MokR W Wong
Jan 4, 2001·Rheumatology·M J MirzayanT Witte
Jun 5, 2002·Lupus·N A DayalD A Isenberg
Feb 1, 2007·Arthritis and Rheumatism·Mónica FernándezUNKNOWN LUMINA Study Group
Mar 6, 2008·The Journal of Medical Investigation : JMI·Reiko TomiokaSaburo Sone
Jan 2, 2009·Scandinavian Journal of Rheumatology·H LaustrupP Junker

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Citations

May 30, 2013·Rheumatology International·Nancy J OlsenDavid R Karp
Dec 11, 2013·Rheumatology International·Jee-Seon ShimSang-Cheol Bae
Apr 18, 2014·Annals of the Rheumatic Diseases·Ronald F van VollenhovenMatthias Schneider
Dec 2, 2014·Rheumatic Diseases Clinics of North America·Julie M Robertson, Judith A James
Nov 10, 2013·Journal of Occupational and Environmental Medicine·Siva NarayananEmily Durden
Jun 10, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Gudrun E NorbyInge-Margrethe Gilboe
Aug 9, 2012·Expert Opinion on Biological Therapy·Alberta Y Hoi, Geoffrey O Littlejohn
Jul 30, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Pei-Chun ChanJing-Long Huang
Aug 23, 2011·Medicine·Maria D AlonsoMiguel A Gonzalez-Gay
Mar 10, 2016·Current Rheumatology Reports·David Fernandez, Kyriakos A Kirou
Feb 18, 2015·Clinical Rheumatology·Zhen ChenXiao-Feng Zeng
Feb 1, 2014·Autoimmunity Reviews·Andrea DoriaLeonardo Punzi
Mar 10, 2015·Autoimmunity Reviews·Fulvia CeccarelliFabrizio Conti
Oct 7, 2016·Annals of the Rheumatic Diseases·Andrea DoriaLuca Iaccarino
Mar 23, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Nasrin AsgariAnne Voss
Sep 21, 2017·Clinical Rheumatology·Liying PengXiaofeng Zeng
May 17, 2011·The Journal of Rheumatology·Irlapati Rajendra VaraprasadGumdal Narsimulu
Mar 1, 2017·Lupus Science & Medicine·Noémi GyöriMichelle Petri
Oct 14, 2017·Rheumatology·Caroline GordonUNKNOWN British Society for Rheumatology Standards, Audit and Guidelines Working Group
Apr 3, 2019·Experimental and Therapeutic Medicine·Yi YuanZhenyu Jiang
Aug 1, 2015·Annals of the Rheumatic Diseases·Margherita ZenAndrea Doria

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