SLE mortality remains disproportionately high, despite improvements over the last decade

Lupus
Ram R Singh, E Y Yen

Abstract

Despite a marked improvement in 10-year survival for systemic lupus erythematosus (SLE) patients over the past five decades, mortality rates from SLE remain high compared to those in the general population. SLE was also among the leading causes of death in young women in the United States during 2000-2015. However, it is encouraging that SLE mortality rates and the ratios of SLE mortality rates to non-SLE mortality rates have decreased every year since the late 1990s. Despite this improvement, disparities in SLE mortality persist according to sex, race, age, and place of residence. Furthermore, demographic and geographic variables seem to modify the effect of each other in influencing SLE mortality, leading to interactions between sex/race/ethnicity-associated factors and geographic differences. In other words, individuals of the same sex/race/ethnicity had differences in SLE mortality depending on where they lived. These observations highlight SLE as an important public health issue. The recognition of SLE as a leading cause of death in the general population might spur targeted public health programs and research funding to address the high lupus mortality.

References

Aug 1, 1971·Annals of Internal Medicine·A D SteinbergJ L Decker
Sep 1, 1971·Arthritis and Rheumatism·M SztejnbokD Kaplan
Aug 26, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D Glicklich, A Acharya
Jan 27, 1999·Arthritis and Rheumatism·K M UramotoS E Gabriel
Apr 1, 1953·Annals of Internal Medicine·R A JESSARC RAGAN
Jun 30, 1956·Journal of the American Medical Association·J F MULLINSC J WILSON
Jan 1, 1952·The American Journal of the Medical Sciences·S A M JOHNSON, O O MEYER
Jul 27, 2006·Arthritis and Rheumatism·S BernatskyR Ramsey-Goldman
Sep 17, 2008·The Journal of Rheumatology·Murray B UrowitzVernon T Farewell
Aug 23, 2011·Medicine·Maria D AlonsoMiguel A Gonzalez-Gay
May 5, 2012·Arthritis Care & Research·Bevra H HahnUNKNOWN American College of Rheumatology
Oct 15, 2013·Arthritis Care & Research·Jinoos YazdanyKaren H Costenbader

❮ Previous
Next ❯

Citations

Oct 29, 2019·Expert Opinion on Drug Safety·Leanna M Wise, William Stohl
Apr 7, 2020·American Journal of Physiology. Renal Physiology·Li XiangGuoshuang Xu
Aug 19, 2020·Rheumatology·Takayuki KatsuyamaVaishali R Moulton
Aug 26, 2020·Lupus·Juan Carlos Hernández-RodríguezJose Juan Pereyra-Rodríguez
Aug 16, 2019·Lupus Science & Medicine·Susan ManziKaren Costenbader
Feb 19, 2019·The Journal of Clinical Investigation·Yashaar ChaichianMichael H Weisman
Jan 25, 2020·Nature Reviews. Disease Primers·Hans-Joachim AndersChandra Mohan
Oct 6, 2020·The Journal of the American Osteopathic Association·Jonathan A Aun, Matthew J Hubbard
Oct 14, 2020·Trends in Molecular Medicine·Marilyn E AllenGregory L Szeto
Feb 26, 2021·Expert Opinion on Biological Therapy·Roberto DepascaleLuca Iaccarino
Feb 19, 2021·MMWR. Morbidity and Mortality Weekly Report·Milena A GianfrancescoJinoos Yazdany
Sep 29, 2020·Rheumatic Diseases Clinics of North America·Shilpa Arora, Jinoos Yazdany
Nov 24, 2021·ACS Biomaterials Science & Engineering·Marilyn E AllenGregory L Szeto
Jan 15, 2022·Current Cardiology Reports·Shrilekha SairamKunal Mishra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.