Sleep- and circadian rhythm-associated pathways as therapeutic targets in bipolar disorder

Expert Opinion on Therapeutic Targets
Frank BellivierJan Scott

Abstract

Disruptions in sleep and circadian rhythms are observed in individuals with bipolar disorders (BD), both during acute mood episodes and remission. Such abnormalities may relate to dysfunction of the molecular circadian clock and could offer a target for new drugs. This review focuses on clinical, actigraphic, biochemical and genetic biomarkers of BDs, as well as animal and cellular models, and highlights that sleep and circadian rhythm disturbances are closely linked to the susceptibility to BDs and vulnerability to mood relapses. As lithium is likely to act as a synchronizer and stabilizer of circadian rhythms, we will review pharmacogenetic studies testing circadian gene polymorphisms and prophylactic response to lithium. Interventions such as sleep deprivation, light therapy and psychological therapies may also target sleep and circadian disruptions in BDs efficiently for treatment and prevention of bipolar depression. We suggest that future research should clarify the associations between sleep and circadian rhythm disturbances and alterations of the molecular clock in order to identify critical targets within the circadian pathway. The investigation of such targets using human cellular models or animal models combined with...Continue Reading

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Citations

Jan 15, 2016·International Journal of Bipolar Disorders·Ashlee B GriersonJan Scott
Jun 20, 2016·Journal of Affective Disorders·Pierre Alexis GeoffroyFrank Bellivier
Sep 16, 2016·Oxidative Medicine and Cellular Longevity·Antonina LucaMaria Luca
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Jun 5, 2019·The Australian and New Zealand Journal of Psychiatry·Gin S Malhi, Lauren Irwin
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Oct 30, 2020·Psychiatry Investigation·Ji Won YeomHeon-Jeong Lee
Feb 14, 2021·Journal of Affective Disorders·Bruno EtainJan Scott
Mar 11, 2021·Neuroscience and Biobehavioral Reviews·Joanne S CarpenterIan B Hickie

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