PMID: 11903863Mar 21, 2002Paper

Sleep and daytime sleepiness in retinitis pigmentosa patients

Journal of Sleep Research
D IonescuC M Shapiro

Abstract

We examined sleep, daytime sleepiness and the ability to stay awake during the day in patients affected with retinitis pigmentosa (RP), to further delineate the role of photoreceptors in the circadian cycle. Twelve individuals diagnosed with RP (40 +/- 8 years) And 12 normally sighted healthy individuals (39 +/- 7 years) matched for age, body mass index (BMI) and sex were selected for the study. Participants had their sleep recorded on two consecutive nights and were monitored on the two following days. On the first day, their ability to stay awake and on the second, their sleep propensity were assessed using the Maintenance of Wakefulness Test (MWT) and the Multiple Sleep Latency Test (MSLT), respectively. Self-report measures were obtained using the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Toronto Hospital Alertness Test (THAT). Subjective daytime sleepiness (ESS: 9 +/- 5 vs. 6 +/- 4, P=0.053) and objectively measured sleep propensity (MSLT: 10 +/- 5 vs. 17 +/- 3 min, P < 0.000) were significantly higher in RP patients than controls, whilst their alertness (THAT: 29 +/- 9 vs. 38 +/- 7, P=0.016) and ability to stay awake (MWT: 21 +/- 9 vs. 29 +/- 2 min, P=0.006) were significantly redu...Continue Reading

Citations

Jul 10, 2003·Psychological Assessment·Douglas W LevineSally A Shumaker
Jun 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Susan E DoyleMichael Menaker
Sep 2, 2008·The British Journal of Ophthalmology·P L Turner, M A Mainster
May 10, 2013·PloS One·Huaizhou WangNingli Wang
Feb 16, 2010·Optometry : Journal of the American Optometric Association·Joseph N Trachtman
Nov 8, 2008·Mayo Clinic Proceedings·E Andrew WallerJoseph Kaplan
Feb 15, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ava K Kiser, Gislin Dagnelie
Nov 11, 2010·Journal of Pineal Research·Pedro LaxNicolás Cuenca
Jul 31, 2014·Journal of Neuroendocrinology·D J van WamelenD F Swaab
Jun 9, 2017·Chronobiology International·Diego Grasel BarbosaÉrico Pereira Gomes Felden
Sep 1, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Ava Katherine BittnerMichael T Smith
Feb 18, 2017·Frontiers in Psychiatry·Colin ShapiroValérie Olivier
Jul 3, 2019·International Journal of Molecular Sciences·Pedro LaxNicolás Cuenca
Mar 18, 2003·Chronobiology International·Timothy H MonkDavid J Kupfer
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Chunbo YangMajlinda Lako

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