Sleep and Pathological Wakefulness at the Time of Liberation from Mechanical Ventilation (SLEEWE). A Prospective Multicenter Physiological Study

American Journal of Respiratory and Critical Care Medicine
Martin DresLaurent Brochard

Abstract

Rationale: Abnormal patterns of sleep and wakefulness exist in mechanically ventilated patients. Objectives: In this study (SLEEWE [Effect of Sleep Disruption on the Outcome of Weaning from Mechanical Ventilation]), we aimed to investigate polysomnographic indexes as well as a continuous index for evaluating sleep depth, the odds ratio product (ORP), to determine whether abnormal sleep or wakefulness is associated with the outcome of spontaneous breathing trials (SBTs). Methods: Mechanically ventilated patients from three sites were enrolled if an SBT was planned the following day. EEG was recorded using a portable sleep diagnostic device 15 hours before the SBT. The ORP was calculated from the power of four EEG frequency bands relative to each other, ranging from full wakefulness (2.5) to deep sleep (0). The correlation between the right and left hemispheres' ORP (R/L ORP) was calculated. Measurements and Main Results: Among 44 patients enrolled, 37 had technically adequate signals: 11 (30%) passed the SBT and were extubated, 8 (21%) passed the SBT but were not deemed to be clinically ready for extubation, and 18 (49%) failed the SBT. Pathological wakefulness or atypical sleep were highly prevalent, but the distribution of cla...Continue Reading

Associated Clinical Trials

Sep 17, 2019·Matthias Eikermann

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Citations

Mar 2, 2019·American Journal of Respiratory and Critical Care Medicine·Dimitris Georgopoulos, Katerina Vaporidi
Dec 8, 2019·American Journal of Respiratory and Critical Care Medicine·Christophe RaultXavier Drouot
Jan 18, 2020·American Journal of Respiratory and Critical Care Medicine·Franco Laghi, Hameeda Shaikh
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May 21, 2019·American Journal of Respiratory and Critical Care Medicine·Martin DresLaurent Brochard
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Oct 20, 2020·Frontiers in Neurology·Marietou DaouM Elizabeth Wilcox
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Feb 16, 2021·ERJ Open Research·Adelaide WithersMaxime Patout
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May 9, 2021·Annals of Intensive Care·Arnaud W ThilleXavier Drouot
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Jul 1, 2021·Critical Care : the Official Journal of the Critical Care Forum·Xueyan YuanLing Liu
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Aug 17, 2021·Critical Care Explorations·Dimitris GeorgopoulosMagdy Younes

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Methods Mentioned

BETA
Sedation

Clinical Trials Mentioned

NCT02464735

Software Mentioned

SLEEWE
Sleepware

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