Sleep and psychiatric abnormalities in Gullian Barré Syndrome

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Wafik Said BahnasyIbrahim Salah Eldeen Ibrahim

Abstract

The sensori-motor manifestations of Guillain Barré Syndrome (GBS) are usually severe enough to mask the psychiatric and sleep problems which are in need for more attention for better functional outcome. This study was performed on 20 GBS patients and 10 healthy controls. Patients were evaluated initially before immunotherapy using the Overall Disability Sum Score (ODSS), Neuropathy Pain Scale (NPS), Hamilton Anxiety Scale (HAS), Montgomery-Åsberg Depression Rating Scale (MADRS) and one-night polysomnography (PSG) followed by the multiple sleep latency test (MSLT) to evaluate the mean sleep latencies. Reevaluation was done using the same parameters 1 month after completing immunotherapy. The study showed significant increase in HAS in GBS patients which were positively correlated with the degree of motor disability. The mean sleep latencies of MSLT were significantly shortened and PSG showed shortening of the total sleep time, sleep efficiency, lowest O2 saturation and pulse transit time with increased wake after sleep onset, sleep stage transition index, apnea hypopnea index, desaturation index, arousal index, snore index and periodic limb movement index. One month after immunotherapy, the anxiety symptoms and sleep abnormaliti...Continue Reading

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Citations

Jul 16, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alex Iranzo
Apr 1, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michelle F Devine, Erik K St Louis

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