PMID: 8959764Jan 1, 1996Paper

Sleep and signs of attention during 3 months of intranasal vasopressin: a pilot study in two elderly subjects

Peptides
B PerrasHorst L Fehm

Abstract

Prominent features of aging include a decrease of attention abilities and loss of sleep. Although acute effects of vasopressin (VP) on these functions in the elderly remained inconsistent, beneficial effects of the peptide may develop only with subchronic treatment, which so far has not been tested. This pilot study examined the changes in: i) event-related brain potentials (ERPs) during an attention task, ii) mood, and iii) nocturnal sleep in two healthy elderly subjects during a 3-month period of VP treatment (40 IU/day). The period of VP treatment was preceded and followed by 4-week periods of placebo treatment. ERPs and mood were not consistently affected by VP. However, unexpectedly, VP improved sleep by markedly enhancing nocturnal slow-wave sleep (SWS, p < 0.05). These findings indicate that effects of subchronic treatment with VP involve mechanisms different from those mediating acute effects.

References

Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·J M Van ReeD De Wied
Jun 26, 2001·Psychiatry and Clinical Neurosciences·T HoriUNKNOWN Sleep Computing Committee of the Japanese Society of Sleep Research Society

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Citations

Oct 18, 2000·European Journal of Pharmacology·H L FehmJ Born
Aug 1, 1997·Psychoneuroendocrinology·B PerrasR Pietrowsky
Feb 6, 1999·Journal of Clinical Psychopharmacology·B PerrasH Lorenz Fehm
May 25, 2010·Psychoneuroendocrinology·Anat PerryRichard P Ebstein
May 1, 2004·The Journal of Urology·Paul EggertDominik Müller

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