Sleep and sleep-wake cycle in an 81-year-old patient with de novo ultra-rapid cycling bipolar disorder

European Archives of Psychiatry and Clinical Neuroscience
R SchreinerM H Wiegand

Abstract

This is a case report of an 81-year-old man who developed de novo bipolar disorder with ultrarapid cycling at the age of 80. Mood was self-rated daily over a period of ten weeks; in addition, polysomnographic and motor activity recordings were performed during a drug-free baseline period. Both depressive and hypomanic episodes had an average duration of about 30 hours; the affective cycle was thus independent from the sleep-wake cycle. When mood shifts occurred during nighttime, sleep was different in nights following depression than in nights following hypomania. Positron emission tomography revealed a moderate bilateral frontal hypermetabolism in the hypomanic phase and yielded normal findings for the depressive stage. In contrast to what is usually expected in ultra-rapid cycling bipolar disorder, this case demonstrates an unusual sleep-unrelated cycle duration in the oldest reported patient so far.

Citations

Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kyu Young LeeYong Sik Kim
May 25, 2010·Psychiatry Research·Kathrin Wilk, Ulrich Hegerl
Sep 15, 2015·Journal of Affective Disorders·Musa SamiRamin Nilforooshan
Mar 12, 2008·Bipolar Disorders·Michael BauerRalph Kupka
Jul 16, 2005·Annals of Medicine·Hader A MansourVishwajit L Nimgaonkar
Dec 6, 2005·The Psychiatric Clinics of North America·Robert C Young
Aug 4, 2005·Chronobiology International·Hader A MansourVishwajit L Nimgaonkar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.