Sleep Apnea Increases the Risk of New Hospitalized Atrial Fibrillation: A Historical Cohort Study

Chest
Tetyana KendzerskaRichard S Leung

Abstract

This study examined the relationship between newly diagnosed OSA and incident hospitalized atrial fibrillation (AF) over the subsequent 10 years in a large arrhythmia-free cohort. Adults referred between 1994 and 2010 to a large academic hospital with suspected OSA who were arrhythmia-free at the time of the first diagnostic sleep study were included. Clinical data were linked to provincial health administrative data to define outcome. Cox regressions were used to investigate the relationship between severity of OSA as measured by the apnea-hypopnea index (AHI) and degree of nocturnal hypoxemia, and incident hospitalized AF. In total, 8,256 subjects were included in this study. Their median age was 47 years, 62% were men; 28% had an AHI > 30 events per hour, and 6% spent > 30% of sleep time with oxygen saturation < 90%. Over a median follow-up of 10 years (interquartile range, 7-13 years), 173 participants (2.1%) were hospitalized with AF. Controlling for age, sex, alcohol consumption, smoking status, previous heart failure, COPD, and pulmonary embolism, nocturnal hypoxemia (but not AHI) was a significant predictor of incident AF: hazard ratio, 2.47 (95% CI, 1.64-3.71). After further controlling for BMI and hypertension, this a...Continue Reading

Citations

Oct 1, 2019·Anesthesia and Analgesia·Kunal KaramchandaniAllan J Walkey
Aug 18, 2020·Internal and Emergency Medicine·Morohunfolu AkinnusiAli Albert El-Solh
Aug 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Cecily S FasslerSusan M Pinney
Oct 7, 2020·Biomarkers in Medicine·Zhaojia WangTong Liu
Feb 7, 2020·Sleep Medicine·Tetyana KendzerskaAndrea S Gershon
Mar 8, 2021·International Archives of Occupational and Environmental Health·Chen-Cheng YangNorito Kawakami
Mar 13, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Manuel Sánchez-de-la-TorreFerran Barbé

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