Sleep before and after temporal lobe epilepsy surgery

Seizure : the Journal of the British Epilepsy Association
Anna SerafiniArielle Crespel

Abstract

Patients with epilepsy often complain of non-restorative sleep. This is the consequence of the acute effect of seizures and the chronic effect of epilepsy responsible for disrupting sleep architecture. Other factors such as antiepileptic drugs (AEDs), also play a role in the alteration of sleep organization. The aim of this study was to evaluate the specific effect of seizures and interictal epileptiform abnormalities (IEAs) on sleep, in particular to see whether reducing seizure frequency by epilepsy surgery might improve sleep organization in these patients. Eleven patients with refractory mesial temporal lobe epilepsy, who underwent surgical treatment and who were seizure free at the follow-up, were included in the study. Treatment with AEDs was not significantly modified before the second year of follow-up. Patients were evaluated before surgery, at 1-year and 2-year follow-up visits with a videoEEG monitoring (24h/24). At each follow-up visit, interictal epileptiform abnormalities and sleep macrostructure parameters were assessed. All patients showed a reduction of their IEAs. At 1-year follow-up, total sleep time and REM sleep increased significantly (p=0.032 and p=0.006, respectively). At 2-year follow-up, an important i...Continue Reading

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Citations

Dec 3, 2014·Child and Adolescent Psychiatric Clinics of North America·Madeleine M Grigg-Damberger, Nancy Foldvary-Schaefer
Aug 6, 2013·Epilepsy & Behavior : E&B·Bhanu Jaseja, Harinder Jaseja
Oct 21, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Miki NakamuraNobukazu Nakasato
Sep 26, 2014·Clinical EEG and Neuroscience·Harinder Jaseja
Feb 3, 2018·Sleep·Shobi SivathambooTerence J O'Brien
Sep 28, 2018·Current Treatment Options in Neurology·Joseph T Daley, Jennifer L DeWolfe
Aug 25, 2020·Annals of Neurology·Laure Peter-DerexBirgit Frauscher
Nov 29, 2020·World Neurosurgery·Harinder JasejaPriyadarshini Mishra
May 25, 2021·Epilepsy Currents·David King-Stephens

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