Sleep, circadian rhythm, and gut microbiota.

Sleep Medicine Reviews
Brittany A MatenchukAnita L Kozyrskyj

Abstract

From asthma and heart disease to diabetes and obesity, the human microbiome plays a role in the pathogenesis of each chronic health condition plaguing today's society. Recent work has shown that the gut microbiota and its metabolites exhibit diurnal rhythmicity which predominantly respond to the feeding/fasting cycle. Persistent jet lag, an obesogenic diet, and clock gene deficiency can dampen the oscillatory nature of gut bacterial composition, which can subsequently be rescued by time restricted feeding. Contrastingly, gut microbial metabolites influence central and hepatic clock gene expression and sleep duration in the host and regulate body composition through circadian transcription factors. Both sleep fragmentation and short sleep duration are associated with gut dysbiosis which may be due to activation of the HPA-axis. Metabolic disturbances associated with sleep loss may in fact be mediated through the overgrowth of specific gut bacteria. Reciprocally, the end products of bacterial species which grow in response to sleep loss are able to induce fatigue. Furthermore, probiotic supplementation has been found to improve subjective sleep quality. Sleep quality and duration may be an important target for supporting healthy ...Continue Reading

References

Feb 1, 1991·The American Journal of Physiology·M R Opp, J M Krueger
Aug 1, 1971·The Journal of Physiology·V FenclJ R Pappenheimer
Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J R PappenheimerC A Goodrich
Sep 3, 1984·European Journal of Pharmacology·I ToblerA Fontana
Jun 1, 1984·The American Journal of Physiology·J M KruegerL Chedid
Apr 8, 1998·The American Journal of Physiology·J FangJ M Krueger
Feb 13, 1999·Cell·J C Dunlap
Apr 13, 1999·The American Journal of Physiology·S TakahashiJ M Krueger
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C A Everson, L A Toth
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·W T ShearerD F Dinges
Apr 17, 2001·Journal of Biological Rhythms·U AlbrechtC C Lee
Feb 21, 2004·Journal of the American College of Cardiology·Hans K Meier-EwertJanet M Mullington
Mar 10, 2004·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Katherine Finn DavisGary L Montgomery
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·A N VgontzasG P Chrousos
Oct 12, 2005·Current Opinion in Pulmonary Medicine·Fotis KapsimalisMeir Kryger
Jan 9, 2008·Nature Reviews. Microbiology·Harry J FlintBryan A White
Feb 2, 2008·Obesity·Sanjay R Patel, Frank B Hu
Jun 4, 2008·Sleep·Francesco P CappuccioMichelle A Miller
Nov 6, 2008·Nature Reviews. Neuroscience·James M KruegerJaak Panksepp
Dec 17, 2008·Current Pharmaceutical Design·James M Krueger
Jan 1, 2007·Sleep Medicine Clinics·James M KruegerLynn Churchill
Feb 12, 2009·Nature Reviews. Neuroscience·Luca Imeri, Mark R Opp
Dec 2, 2009·The European Respiratory Journal·A L KozyrskyjP D Sly
Apr 27, 2010·Innate Immunity·Roman Dziarski, Dipika Gupta
Oct 16, 2010·BMC Public Health·Zumin ShiJames Martin
May 3, 2011·Sleep·Michelle Lampl, Michael L Johnson
Jun 28, 2011·PloS One·Jorge M DinisCleber C Ouverney
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bärbel StecherWolf-Dietrich Hardt
May 26, 2012·The European Journal of Neuroscience·Eiko Nakamaru-OgisoKatsuji Takai
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Jun 14, 2013·Biological Psychiatry·Timothy G DinanJohn F Cryan

❮ Previous
Next ❯

Citations

Nov 13, 2020·Expert Opinion on Therapeutic Targets·Mohammad BadranDavid Gozal
Nov 10, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Magdalena KoszewiczGjumrakch Aliev
Feb 2, 2021·Science China. Life Sciences·Jia LuoFeng Jin
Jan 11, 2021·Seminars in Cell & Developmental Biology·Annelise A Madison, Janice K Kiecolt-Glaser
Apr 4, 2021·International Journal of Molecular Sciences·Thomas M BarberMartin O Weickert
Jun 19, 2021·Frontiers in Cellular and Infection Microbiology·Qing LiSheng-Liang Chen
Sep 11, 2021·Molecular Nutrition & Food Research·Yen-Chun KohMin-Hsiung Pan
Nov 3, 2021·Journal of Agricultural and Food Chemistry·Shanshan HuLiang Zeng
Oct 28, 2021·The Journal of Physiology·Grace L BurnsSimon Keely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.