PMID: 9629952Jun 18, 1998Paper

Sleep cluster arousal analysis and treatment response to heterocyclic antidepressants in patients with major depression

Journal of Affective Disorders
J StaedtG Stoppe

Abstract

A close link between sleep normalisation and antidepressant response in depressed patients has been reported. We attempt to separate early antidepressant treatment responders from nonresponders by the use of sleep EEG recordings. Sleep EEG recordings were performed in 20 inpatients with a unipolar major depressive disorder during the first and third week of treatment with heterocyclic antidepressants. Acute treatment polygraphic measures with microarousal analysis were used to predict response. Response was defined as a minimum reduction of > or = 30% in the v. Zerssen Depression Scale after 3 weeks. Compared to the 11 nonresponders, the 9 responders initially showed a highly significant increase of arousals during sleep quantified with the cluster disturbed sleep (CDS), whereas the classical sleep parameters (REM, stage I-IV) had no predictive value. The validity of our results is limited by the small number of patients and the lacking randomised assignment. Nevertheless the results are still interesting. Because the CDS clearly separated responders from nonresponders at treatment onset. This could be due to a different reagibility of the catecholaminergic system. The data indicate that the CDS can be helpful for the predictio...Continue Reading

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Citations

May 29, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Michal KahnAvi Sadeh
Nov 13, 2003·Journal of Affective Disorders·Benedetto FarinaEllen Frank
Jul 14, 1999·Journal of Affective Disorders·M E Thase, E S Friedman
Jan 6, 2000·Psychiatry Research·R E PolandK M Lin
Feb 8, 2003·Psychoneuroendocrinology·I A AntonijevicA Steiger
May 19, 2000·Research in Developmental Disabilities·F J SymonsT Thompson
Feb 19, 2000·International Journal of Geriatric Psychiatry·J StaedtG Stoppe
Aug 1, 2003·Acta Neuropsychiatrica·Harald Murck
Mar 5, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Bruce Nicholson, Sunil Verma
Feb 6, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Emily HanzlikJessica Duis
Oct 9, 2007·CNS Spectrums·G WintererR Coppola
Feb 7, 2019·The Pharmacogenomics Journal·Aurelia ViglioneIgor Branchi

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