Sleep-dependent surges in growth hormone do not contribute to sleep-dependent memory consolidation

Psychoneuroendocrinology
S GaisJan Born

Abstract

In the search for the mechanisms that mediate the effects of sleep on the consolidation of memories, growth hormone (GH) recently became of interest, because in humans it is released mainly during slow-wave sleep (SWS), a period of enhanced declarative memory consolidation. In addition, recent studies showed that GH is involved in proper memory function in GH deficient and elderly humans and this effect has been linked to regulatory influences of GH on hippocampal NMDA receptors. Here, we blocked GH secretion by intravenous infusion of somatostatin in healthy young subjects during the first 3 h of sleep, which contain mainly SWS. Declarative and procedural memory consolidation was tested across this period, using a word pair association task and a mirror tracing task, respectively. Although GH was effectively suppressed, memory performance as well as sleep were entirely unaffected by this suppression. Whereas GH may in the long run generally support brain systems required for maintaining proper memory function, our data exclude a necessary contribution of the nocturnal surge in pituitary GH secretion to the acute processing and formation of specific memories during sleep.

References

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Aug 26, 1999·Trends in Cognitive Sciences·M E Hasselmo
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Madeleine Le GrevèsFred Nyberg
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Citations

Jul 12, 2011·Trends in Neurosciences·Sara C MednickJohn T Wixted
Dec 1, 2009·Obstetrics and Gynecology Clinics of North America·Jan Born, Ullrich Wagner
Jun 30, 2009·Journal of Psychiatric Research·Mareen Seeck-HirschnerRobert Göder
Oct 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gordon B FeldManfred Hallschmid
Apr 26, 2014·Frontiers in Systems Neuroscience·Susanne Diekelmann
Apr 17, 2013·Physiological Reviews·Björn Rasch, Jan Born
Apr 10, 2018·Trends in Neurosciences·Kristine A WilckensDaniel J Buysse

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