Sleep deprivation after septic insult increases mortality independent of age

The Journal of Trauma
Randall S FrieseC M Sinton

Abstract

Sleep deprivation is a common problem in the intensive care unit. Animal models have demonstrated that sleep deprivation alone is associated with increased mortality. We have previously shown that septic insult with sleep deprivation results in increased mortality in a murine model. The aging process is known to reduce the restorative phases of sleep. The purpose of this study was to evaluate the effect of age on mortality with sleep deprivation during recovery from septic insult. C57BL/6J male mice aged 2 months (young) or 9 months (old) underwent cecal ligation and puncture (CLP). Animals were randomized to receive sleep interruption (SI) for 48 hours or standard recovery (no SI). Sham animals underwent laparotomy and cecal manipulation without puncture. SI was achieved by securing animal housing to an orbital shaker set to repeatedly cycle at 30 rpm over 120 seconds (30 seconds on/90 seconds off). The primary outcome was survival at 5 days post-CLP. Kaplan-Meier survival analysis with log-rank test was used to explore differences in mortality. SI resulted in an increase in time awake for both light and dark cycles (p < 0.001). Mortality after CLP with SI (n = 30) was 57% and mortality after CLP without SI (controls; n = 33) ...Continue Reading

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Jan 24, 2008·The Journal of Trauma·Randall S FrieseLarry M Gentilello
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Citations

Mar 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Hannah WunschJan Claassen
Sep 6, 2011·Critical Care : the Official Journal of the Critical Care Forum·Mervyn Singer, Michael A Matthay
Mar 15, 2016·Sleep Medicine Clinics·Xavier Drouot, Solene Quentin
May 4, 2012·Chest·Saiprakash B Venkateshiah, Nancy A Collop
Nov 3, 2009·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Agness C Tembo, Vicki Parker
Aug 4, 2009·Journal of Neuroscience Methods·Christopher M SintonRandall S Friese
Aug 19, 2014·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Christine M GillisRobert L Owens
May 25, 2016·Critical Care Nursing Clinics of North America·Ellyn E MatthewsNatalie A Dumont
Jun 30, 2015·Critical Care Clinics·Xavier Drouot, Solene Quentin
Jun 29, 2013·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Agness C TemboIsabel Higgins
Jun 12, 2014·Journal of Intensive Care Medicine·Lisa M Pulak, Louise Jensen
Mar 29, 2019·Physiological Reviews·Luciana BesedovskyMonika Haack
Jan 5, 2011·Critical Care Medicine·Aimee L Brame, Mervyn Singer
Jul 14, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Chloé JousselmeFabrice Michel
Jul 6, 2020·Nursing in Critical Care·Aylin Aydın SayılanSamet Sayılan
Jan 7, 2020·Brain, Behavior, and Immunity·Julia HahnStella E Autenrieth
Jan 31, 2021·Critical Care : the Official Journal of the Critical Care Forum·L J DelaneyF Van Haren
Dec 10, 2020·Journal of Patient Experience·Ravindranath TiruvoipatiKavi Haji
Jan 13, 2021·PM & R : the Journal of Injury, Function, and Rehabilitation·Shane M DavisJay J Han
Jun 11, 2021·Frontiers in Medicine·Yujing ZhangJiancheng Zhang

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