PMID: 5917781Sep 16, 1966

Sleep deprivation and brain acetylcholine

M B BowersD X Freedman


Rats deprived of D-state sleep (and, to some extent, of slow-wave sleep) for 96 hours show a significant fall in brain acetylcholine in the telencephalon; there were no significant changes in the diencephalon and brain stem. Restraint stress and activity wheel stress produced no significant change in acetylcholine levels in any of these regions; the telencephalic response to sleep deprivation, therefore, cannot be attributed to nonspecific stress. The effects of D-state deprivation and the psychoactive anticholinergic drugs on telencephalic acetylcholine levels are similar.


Oct 11, 1974·Brain Research·W FishbeinD Chattman
May 1, 1968·Electroencephalography and Clinical Neurophysiology·H B CohenW Dement
Jun 1, 1967·Journal of Psychiatric Research·I FeinbergN Heller
Aug 1, 1969·Life Sciences·K TsuchiyaT Kobayashi
Jul 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·Y Saito
Apr 1, 1976·Pharmacology, Biochemistry, and Behavior·P K GhoshG M Ling
May 1, 1991·Pharmacology, Biochemistry, and Behavior·M Thakkar, B N Mallick
Sep 1, 1986·Brain Research·S C Dilsaver
Sep 1, 1989·Behavioral and Neural Biology·P Gisquet-Verrier, C Smith
May 7, 2009·American Journal of Therapeutics·William ShellDavid S Silver
Jan 1, 1969·Journal of Neurochemistry·V Karadzic, B B Mrsulja
Jun 1, 1970·Journal of Neurochemistry·I HaulicaA Haulica
Feb 1, 1968·Journal of Neurochemistry·L HeinerP Mandel
Jan 1, 1988·The International Journal of Neuroscience·R SandykE Labadie
Apr 1, 1977·Behavioral Biology·W Fishbein, B M Gutwein
Feb 1, 1975·Pharmacological Research Communications·M TrabucchiE Costa
Jun 1, 1984·Journal of Neurochemistry·M YamaneI Yanagisawa
May 1, 1975·Archives internationales de physiologie et de biochimie·M LeventalL Rakić
May 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R Camarini, M A Benedito
Feb 1, 1968·Canadian Psychiatric Association Journal·J A Ward
Dec 1, 1972·Archives internationales de physiologie et de biochimie·M Liemans, G Dandrifosse
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad NasehiMohammad-Reza Zarrindast

Related Concepts

Acetylcholine Sulfate (1: 1)
Brain Chemistry
Sleep, Slow-Wave

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.