May 15, 2008

Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs

The International Journal of Neuropsychopharmacology
Roberto FrauMarco Bortolato

Abstract

Sleep deprivation (SD) is known to induce perceptual impairments, ranging from perceptual distortion to hallucinatory states. Although this phenomenon has been extensively described in the literature, its neurobiological underpinnings remain elusive. In rodents, SD induces a series of behavioural patterns that might be reflective of psychosis and mania, such as hyperlocomotion and sensitization to psychotogenic drugs. Notably, such changes are accompanied by transitory alterations of dopaminergic signalling. Based on the hypothesis that both psychotic and manic disorders reflect gating impairments, the present study was aimed at the assessment of the impact of SD on the behavioural model of prepulse inhibition (PPI) of the startle reflex, a reliable paradigm for the study of informational filtering. Rats subjected to SD (24 h, 48 h, 72 h) exhibited a time-dependent increase in startle reflex and a dramatic deficit in PPI. Both alterations were reversed 24 h after termination of the SD period. Interestingly, PPI disruption was efficiently prevented by haloperidol (0.1 mg/kg i.p.) clozapine (5 mg/kg i.p.) and risperidone (1 mg/kg i.p.). Conversely, neither the anxiolytic diazepam (5 mg/kg i.p.) nor the antidepressant citalopram (...Continue Reading

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References

Mentioned in this Paper

Insufficient Sleep Syndrome
Antipsychotic Effect
Assay OF Haloperidol
Clozapine
Soleus Muscle Structure
Bipolar Disorder
Startle Reaction
Prepulse Inhibition Activity
Acoustic Stimulation
Haloperidol

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