Sleep deprivation disrupts the lacrimal system and induces dry eye disease

Experimental & Molecular Medicine
Sanming LiWei Li

Abstract

Sleep deficiency is a common public health problem associated with many diseases, such as obesity and cardiovascular disease. In this study, we established a sleep deprivation (SD) mouse model using a 'stick over water' method and observed the effect of sleep deficiency on ocular surface health. We found that SD decreased aqueous tear secretion; increased corneal epithelial cell defects, corneal sensitivity, and apoptosis; and induced squamous metaplasia of the corneal epithelium. These pathological changes mimic the typical features of dry eye. However, there was no obvious corneal inflammation and conjunctival goblet cell change after SD for 10 days. Meanwhile, lacrimal gland hypertrophy along with abnormal lipid metabolites, secretory proteins and free amino-acid profiles became apparent as the SD duration increased. Furthermore, the ocular surface changes induced by SD for 10 days were largely reversed after 14 days of rest. We conclude that SD compromises lacrimal system function and induces dry eye. These findings will benefit the clinical diagnosis and treatment of sleep-disorder-related ocular surface diseases.

References

Aug 1, 1990·Ophthalmology·S C PflugfelderS C Tseng
Feb 1, 1989·Sleep·B M BergmannA Rechtschaffen
Nov 29, 2005·Experimental Eye Research·Driss Zoukhri
Jan 21, 2006·American Journal of Respiratory Cell and Molecular Biology·S Marina Casalino-MatsudaRosanna M Forteza
Dec 7, 2007·Investigative Ophthalmology & Visual Science·Aude PaulyChristophe Baudouin
Jan 4, 2008·Investigative Ophthalmology & Visual Science·Shimin LiNancy A McNamara
Mar 11, 2008·Trends in Neurosciences·Jerome M Siegel
Jul 2, 2008·Annals of the New York Academy of Sciences·Kristen L Knutson, Eve Van Cauter
Dec 26, 2008·JAMA : the Journal of the American Medical Association·Christopher Ryan KingDiane S Lauderdale
Apr 21, 2009·Progress in Retinal and Eye Research·Darlene A Dartt
Jun 10, 2009·Archives of Internal Medicine·Kristen L KnutsonDiane S Lauderdale
Jun 21, 2011·American Journal of Ophthalmology·Anat GalorVictor L Perez
Aug 17, 2011·Preventive Medicine·Lela R McKnight-EilyGeraldine S Perry
Aug 1, 2013·Progress in Molecular Biology and Translational Science·Namni GoelDavid F Dinges
Nov 14, 2013·Purinergic Signalling·Kim L BeaucageS Jeffrey Dixon
Dec 10, 2013·Experimental Eye Research·Xiaobo ZhangStephen C Pflugfelder
Jan 17, 2014·The Lancet. Respiratory Medicine·R Nisha Aurora, Naresh M Punjabi
May 17, 2014·Investigative Ophthalmology & Visual Science·Young Bok LeeYoung Joo Shin
Jun 6, 2014·PloS One·Takaaki InabaKazuo Tsubota
Aug 20, 2014·The Medical Clinics of North America·Eliza L Sutton
Aug 20, 2014·Current Psychiatry Reports·Deirdre A Conroy, J Todd Arnedt
Aug 27, 2014·Clinics in Chest Medicine·Dennis OyiengoGhada Bourjeily
Apr 8, 2015·Neuropsychiatric Disease and Treatment·Masahiko AyakiKazuo Tsubota
Jul 5, 2015·Sleep Medicine·Michelle A Short, Mia Louca
Oct 27, 2015·Sleep Medicine·Wanhyung LeeJin-Ha Yoon
Dec 3, 2015·The American Journal of Pathology·Yen-Chiao WangWei Li
Mar 2, 2016·Scientific Reports·Masahiko AyakiKazuo Tsubota
Mar 5, 2016·Neuropsychiatric Disease and Treatment·Masahiko AyakiKazuo Tsubota
Jul 21, 2016·Scientific Reports·Natarajan PerumalFranz H Grus

❮ Previous
Next ❯

Citations

Mar 14, 2020·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Maria MarkoulliKatie Edwards
Jan 19, 2019·Investigative Ophthalmology & Visual Science·Liying TangZuguo Liu
Jan 10, 2021·The Ocular Surface·Morten Schjerven MagnoJelle Vehof
Sep 22, 2020·Sleep Medicine·Siaw Cheok Liew, Thidar Aung
Mar 7, 2021·Biomolecules·Alejandro Martínez-ÁguilaGonzalo Carracedo
Mar 30, 2021·Journal of Clinical Psychopharmacology·Jeffrey J RakofskyBoadie W Dunlop
Apr 29, 2021·Risk Management and Healthcare Policy·Pietro Emanuele NapoliMaurizio Fossarello
Jun 11, 2021·Scientific Reports·Nutnicha NetiPitipol Choopong
Jul 29, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Azadeh Tavakoli, Judith Louise Flanagan
Aug 8, 2021·Journal of Clinical Medicine·Pei-Kang LiuMing-Ju Tsai
Sep 14, 2020·The American Journal of Pathology·Xin HeWei Li

❮ Previous
Next ❯

Methods Mentioned

BETA
reverse transcription-PCR
PCR
scanning
transmission electron microscopy
RNA-seq

Software Mentioned

Olympus Fluoview
SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Journal of Ophthalmology
Chuanqing DingLei Zhou
Bulletin des sociétés d'ophtalmologie de France
J L George
Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Seul Min ChoiMoohi Yoo
© 2022 Meta ULC. All rights reserved