PMID: 9177956Jan 1, 1997Paper

Sleep deprivation hastens the antidepressant action of fluoxetine

European Archives of Psychiatry and Clinical Neuroscience
F BenedettiE Smeraldi

Abstract

Among ten bipolar depressed patients admitted to our psychiatric ward, five patients were treated with fluoxetine alone and five subjects were treated with fluoxetine in association with total sleep deprivation (TSD) in order to evaluate the effect of the interaction between the administration of the serotonergic antidepressant compound fluoxetine and repeated cycles of TSD. Patients treated with fluoxetine plus repeated TSD showed a faster amelioration of depressive symptomatology compared with the other group. We discuss our findings hypothesizing an enhancement in dopaminergic and possibly in serotonergic transmission due to repeated TSD adding to the increase in serotonergic transmission due to fluoxetine medication.

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Citations

Jun 9, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alessandro SerrettiEnrico Smeraldi
Mar 27, 1999·Journal of Psychiatric Research·F BenedettiE Smeraldi
Jul 14, 1999·Journal of Affective Disorders·E LattuadaE Smeraldi
Dec 1, 2001·Psychiatry Research·F BenedettiC Colombo
Jul 24, 1998·Psychiatry Research·B BarbiniE Smeraldi
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Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Renaud MassartLaurence Lanfumey
Dec 29, 2011·Depression Research and Treatment·Chiara BrambillaEnrico Smeraldi
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Jan 26, 2013·Pharmacology & Therapeutics·Laurence LanfumeyMichel Hamon
Aug 11, 2007·Sleep Medicine Reviews·Francesco BenedettiEnrico Smeraldi
Jul 13, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Malcolm Lader
Aug 6, 2008·Human Psychopharmacology·Anne Germain, David J Kupfer
Apr 25, 2012·Bipolar Disorders·Michael BauerAndrea Pfennig
Oct 6, 1999·Comprehensive Psychiatry·A SerrettiE Smeraldi
Jul 28, 2012·Journal of Affective Disorders·Masaru EchizenyaTetsuo Shimizu
Sep 25, 2001·Depression and Anxiety·B L Ringel, M P Szuba
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Nov 5, 2020·Acta Psychiatrica Scandinavica·Michael IoannouSteinn Steingrimsson

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