Sleep deprivation increases brain serotonin turnover in the rat

Neuroreport
M AsikainenT Porkka-Heiskanen

Abstract

IN order to study possible time-dependent changes in serotonin metabolism in rat brain, male Wistar rats were subjected to 3, 6 or 12 h total sleep deprivation (SD) by gentle handling. In addition two groups of rats subjected first to 6 h SD were allowed 2 or 4 h rebound sleep. Tissue concentrations of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were measured from several brain areas using HPLC/ECD. SD significantly increased the 5-HIAA/5-HT ratio in frontal cortex, hippocampus, hypothalamus and brain stem, indicating increased 5-HT turnover in those areas. After 2 and 4 h rebound sleep, the 5-HIAA/5-HT ratio was similar to that in controls. We conclude that a short SD increases 5-HT turnover in the rat brain for the duration of SD only.

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Citations

Jul 1, 2010·Expert Review of Neurotherapeutics·Ulrich-Michael HemmeterJürgen-Christian Krieg
Feb 7, 2012·Sleep Medicine·Jeanine KamphuisMarike Lancel
Oct 23, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P SchestatskyW Caumo
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Jun 6, 2009·The European Journal of Neuroscience·Fabio LongordoAnita Lüthi
May 29, 2009·The European Journal of Neuroscience·H-P Landolt, R Wehrle
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Jan 3, 2006·Sleep Medicine Reviews·Stefan LautenbacherJürgen-Christian Krieg
Mar 17, 2017·The Journal of Pain : Official Journal of the American Pain Society·Stella IacovidesFiona C Baker
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Feb 14, 2006·Neurochemical Research·M SenthilvelanR Shella Devi
Jan 10, 2021·Chinese Journal of Integrative Medicine·Zhi-Hui LiYu-Jie Zhang

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