Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid.

Journal of Neural Transmission
Dagmar KoetheF Markus Leweke

Abstract

This study investigated the role of two fatty acid ethanolamides, the endogenous cannabinoid anandamide and its structural analog oleoylethanolamide in sleep deprivation of human volunteers. Serum and cerebrospinal fluid (CSF) samples were obtained from 20 healthy volunteers before and after a night of sleep deprivation with an interval of about 12 months. We found increased levels of oleoylethanolamide in CSF (P = 0.011) but not in serum (P = 0.068) after 24 h of sleep deprivation. Oleoylethanolamide is an endogenous lipid messenger that is released after neural injury and activates peroxisome proliferator-activated receptor-alpha (PPAR-alpha) with nanomolar potency. Exogenous PPAR-alpha agonists, such as hypolipidemic fibrates and oleoylethanolamide, exert both neuroprotective and neurotrophic effects. Thus, our results suggest that oleoylethanolamide release may represent an endogenous neuroprotective signal during sleep deprivation.

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Citations

Sep 20, 2011·Pflügers Archiv : European journal of physiology·Jonathan P Wisor
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aalim M WeljieAmita Sehgal
Jul 2, 2010·British Journal of Pharmacology·Linda K VaughnCecilia J Hillard
Oct 1, 2016·Psychoneuroendocrinology·Jonathan CedernaesChristian Benedict
Oct 21, 2016·Neuroscience and Biobehavioral Reviews·Oscar Prospéro-GarcíaMónica Méndez-Díaz
Mar 10, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dagmar KoetheF Markus Leweke
Aug 1, 2013·Journal of Clinical Psychopharmacology·Carmen WalterJörn Lötsch
Nov 13, 2019·Current Opinion in Psychiatry·Verity L ChadwickF Markus Leweke
Aug 11, 2020·Frontiers in Molecular Neuroscience·Andrew J Kesner, David M Lovinger
Dec 15, 2010·The American Journal of Clinical Nutrition·Francisco J Rosales
Mar 30, 2021·Frontiers in Psychiatry·Michał GraczykTomasz Dzierzanowski
Jan 10, 2019·Journal of Proteome Research·Carolina Gonzalez-RianoCoral Barbas
Sep 8, 2021·Alzheimer's Research & Therapy·Kamil BorkowskiUNKNOWN Alzheimer’s Disease Metabolomics Consortium

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Methods Mentioned

BETA
sedation

Software Mentioned

SPSS
exactRankTests
R

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