Sleep-Disordered Breathing in Children with Prader-Willi Syndrome in Relation to Growth Hormone Therapy Onset.

Hormone Research in Pædiatrics
Maja ZimmermannBettina Gohlke

Abstract

The aim of this study was to consider sleep apnea in Prader-Willi syndrome (PWS) children depending on age at growth hormone (GH) therapy onset. We analyzed longitudinally cardiorespiratory polygraphy of 62 PWS children (aged 0-2.5 years at baseline). Twenty-one children (Group A) started GH-therapy during and 41 children (Group B) after their first year of life. Data were acquired before, at 3 and 6 months, then 1.2, 2.2, and 3.2 years after GH onset. Outcomes were determined with the obstructive apnea hypopnea index (OAHI), central apnea index (CAI), oxygen desaturation index (ODI), and by measuring obstructive sleep apnea (OSA) and peripheral blood oxygen saturation (SpO2). We observed no significant differences in OAHI, CAI, ODI, and SpO2 depending on treatment onset. At baseline, 5/21 patients (23.8%) in Group A versus 15/41 patients (36.6%) in Group B showed pathological sleep apnea (OAHI ≥1.5). Pathological OSA increased significantly in Group A during the first 3 months of therapy but dropped below baseline after 1 year in both groups. ODI changed during GH therapy in both groups (from 4.0 to 2.6 in Group A, and 3.6 to 1.6 in Group B; baseline to 3.2 years; p < 0.05). OSA in PWS children appears to develop independently...Continue Reading

References

Nov 10, 2001·Annual Review of Genomics and Human Genetics·R D Nicholls, J L Knepper
Dec 17, 2003·Journal of Intellectual Disability Research : JIDR·H-C SteinhausenZ Malin
Jan 15, 2004·The Journal of Pediatrics·Guy Van VlietLuc L Oligny
Dec 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Jennifer MillerMary Wagner
Sep 28, 2006·The Journal of Clinical Endocrinology and Metabolism·D A M FestenA C S Hokken-Koelega
Dec 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Steven D ChernausekUNKNOWN GH Insensitivity Syndrome Collaborative Group
Aug 25, 2007·Clinical Endocrinology·D A M FestenA C S Hokken-Koelega
Jan 19, 2008·American Journal of Medical Genetics. Part a·Graziano GrugniUNKNOWN Genetic Obesity Study Group of Italian Society of Pediatric Endocrinology and Diabetology (ISPED)
Feb 6, 2008·Proceedings of the American Thoracic Society·Julie C Lumeng, Ronald D Chervin
Mar 8, 2008·American Journal of Medical Genetics. Part a·M TauberM Hébert
Aug 14, 2008·The Journal of Clinical Endocrinology and Metabolism·A P GoldstoneUNKNOWN speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS
Apr 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Roderick F A de Lind van WijngaardenAnita C S Hokken-Koelega
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Roderick F A de Lind van WijngaardenAnita C S Hokken-Koelega
Jan 13, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Suzanne B CassidyDaniel J Driscoll
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
Apr 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Cheri L DealUNKNOWN 2011 Growth Hormone in Prader-Willi Syndrome Clinical Care Guidelines Workshop Participants
Jun 25, 2013·Research in Developmental Disabilities·Sin Ting LoAnita Hokken-Koelega
Jul 31, 2013·The Journal of Clinical Endocrinology and Metabolism·Jenny BeriniUNKNOWN Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED)
Sep 5, 2013·The Journal of Clinical Endocrinology and Metabolism·N E BakkerA C S Hokken-Koelega
Apr 16, 2014·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Karim SedkyAndres Pumariega
Apr 9, 2015·Pediatric Pulmonology·Martino PavoneBrigitte Fauroux
Aug 3, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Elisabeth M DykensHailee Hunt-Hawkins
Jan 29, 2017·Archives of Disease in Childhood·Abdullah KhayatSuhail Al-Saleh
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Nienke E BakkerUNKNOWN KIGS Steering Committee
Mar 24, 2017·Journal of Neurodevelopmental Disorders·Akvile LukosheAnita C Hokken-Koelega
Sep 6, 2019·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Viviana Valeria PalmieriUNKNOWN Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology

❮ Previous
Next ❯

Citations

Mar 17, 2021·Expert Review of Endocrinology & Metabolism·Alessandro SalvatoniMassimo Agosti
May 6, 2021·The Journal of Clinical Endocrinology and Metabolism·Hasanain Hamid ShukurCharlotte Hoybye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Jenny BeriniGenetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED)
Expert Review of Endocrinology & Metabolism
Alessandro SalvatoniLaura Calcaterra
Pediatric Pulmonology
M Klein, L G Reynolds
© 2022 Meta ULC. All rights reserved