Sleep Disordered Breathing in Children

Indian Journal of Pediatrics
Christopher Grime, Hui-Leng Tan

Abstract

Sleep-disordered breathing (SDB) refers to a group of disorders characterized by abnormalities of respiration or ventilation during sleep. It encompasses obstructive sleep apnea (OSA), central sleep apnea (CSA) syndromes, sleep-related hypoventilation and sleep-related hypoxemia disorders. This review will concentrate on the disorder most prevalent in pediatrics, i.e., OSA, highlighting the most recent developments in our understanding of the etiology, pathophysiology and treatment options of this condition. OSA morbidities primarily involve the neurocognitive, cardiovascular and metabolic systems. However, there can be significant phenotypic variation in terms of end organ morbidity for the same OSA severity. This is likely due to the interplay between genetic and environmental factors; recent developments in the fields of genomics and proteomics have the potential to shed light on these complex pathological cascades. As we enter the era of personalized medicine, phenotyping patients to enable clinicians to tailor bespoke clinical management plans will be of crucial importance.

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Citations

Aug 27, 2015·Indian Journal of Pediatrics·Andrew Bush, Sushil K Kabra
Apr 22, 2017·Clinical Pediatrics·Emily F BossMary Catherine Beach
May 22, 2021·Journal of Family Medicine and Primary Care·Ali A Al EhaidebAreej A Alsubaie
Aug 10, 2021·Sleep & Breathing = Schlaf & Atmung·Saif Al-YaarubiDoaa Khater

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