Sleep-disordered breathing in deep vein thrombosis and acute pulmonary embolism

The European Respiratory Journal
Michael Arzt"Circulation and Sleep" working group of the German Society of Sleep Research and Sleep Medicine (DGSM)

Abstract

Sleep-disordered breathing (SDB) may trigger thromboembolic events by enhancing intravascular clot formation. The primary objective of the present nested case-control study was to investigate whether the prevalence of SDB is increased in patients with deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). 82 consecutive patients with DVT and/or PE (cases) were prospectively enrolled irrespective of SDB-related symptoms and formed matched pairs with patients without DVT and/or PE (controls) according to sex and pre-defined categories of age and body mass index. The prevalence of SDB (respiratory disturbance index assessed by polygraphy ≥ 15 events·h(-1)) was significantly greater in the cases with DVT and/or PE than in controls (40 versus 26%, p=0.046) and was predominantly obstructive in nature. Multiple regression analysis revealed that SDB was significantly associated with DVT and/or PE (OR 2.28, 95% CI 1.08-4.85; p=0.032) independent of established risk factors for thrombosis. In the sex-specific analyses this association was significant in females (OR 4.14, 95% CI 1.05-16.36; p=0.042), but not in males (OR 1.55, 95% CI 0.57-4.21; p=0.391). SDB occurs more frequently in females with DVT and/or PE than in controls m...Continue Reading

Citations

Jan 24, 2013·Sleep Medicine·Rio DumitrascuRichard Schulz
May 23, 2015·Thrombosis and Haemostasis·Giuseppe LippiMassimo Franchini
Dec 2, 2015·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Farzin GhiasiBabak Amra
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Hans-Joachim EiseleRichard Schulz
Jul 28, 2016·Chest·Alberto Alonso-FernándezFrancisco García-Río
Jan 31, 2018·Journal of the American Heart Association·Erin M HaldJohn-Bjarne Hansen
Nov 6, 2018·The European Respiratory Journal·Alberto García-OrtegaMiguel Ángel Martínez-García
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Oct 23, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·T M BerghausW von Scheidt
Mar 23, 2019·Sleep & Breathing = Schlaf & Atmung·Jing ZhangYubiao Guo

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