Sleep disorders in cystic fibrosis: A systematic review and meta-analysis.

Sleep Medicine Reviews
Joel ReiterErick Forno

Abstract

Cystic fibrosis (CF) is a genetic disorder that leads to airway mucus accumulation, chronic inflammation, and recurrent respiratory infections - all likely impacting sleep. However, controlled studies of sleep in CF patients are limited, and have shown mixed results. We reviewed all publications on CF and sleep indexed in PubMed, CINAHL, and Scopus through April 2019. In the meta-analysis, we calculated pooled weighted mean differences for sleep quality, sleepiness, oximetry, and polysomnographic (PSG) parameters, using fixed or random-effects models as appropriate. A total of 87 manuscripts were reviewed. Compared to controls, children with CF had lower nighttime oxygen saturation nadirs, decreased sleep efficiency and a higher respiratory event index, with no differences in the percentage of REM sleep. Adults with CF had lower oxygen saturation nadirs, with a trend towards reduced sleep efficiency and no differences in REM sleep. In addition, patients with CF cough more during sleep and experience painful events that interfere with sleep. Actigraphy and questionnaires suggest disturbed sleep and daytime sleepiness. Noninvasive ventilation appears to improve gas exchange and symptoms. We conclude that when sleep is evaluated o...Continue Reading

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Citations

Dec 3, 2020·Pediatric Pulmonology·Sugeet K JagpalMaya Ramagopal
Dec 3, 2020·Frontiers in Pediatrics·Emine AtagRefika Ersu
May 12, 2021·Pediatric Pulmonology·Joel ReiterAlex Gileles-Hillel
May 28, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jordana McMurrayRobyn Stremler

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