Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504

The Journal of Clinical Psychiatry
John H KrystalVeterans Affairs Cooperative Study #504 Group

Abstract

Sleep disturbances are common among veterans with chronic military-related posttraumatic stress disorder (PTSD). This article reports the results of a multicenter clinical trial that explored the clinical correlates of reported sleep impairment in these veterans and tested the impact of the second-generation antipsychotic risperidone upon these symptoms. This article reports secondary analyses of a 24-week multicenter randomized placebo-controlled trial of adjunctive risperidone in patients with chronic military-related PTSD symptoms (n = 267, 97% male) who were symptomatic despite treatment with antidepressants and other medications. The study was conducted between February 2007 and February 2010. DSM-IV PTSD diagnoses were made by using the Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Nonpatient Edition. Sleep disturbances were assessed principally by using the Pittsburgh Sleep Quality Index (PSQI) (primary outcome measure). Analyses were conducted using bivariate correlations and longitudinal mixed model regressions. Eighty-eight percent of the patients in this study had clinically significantly impaired sleep on the PSQI. Severity of sleep disturbances correlated with PTSD symptom severity as measured by th...Continue Reading

Citations

Nov 12, 2016·Expert Review of Clinical Pharmacology·Eileen Thomas, Dan J Stein
Jun 6, 2017·Brain, Behavior, and Immunity·Erika J WolfMark W Miller
Mar 10, 2018·Molecular Psychiatry·Murray B SteinRobert J Ursano
Feb 18, 2018·BMC Psychiatry·Richard F ArmentaUNKNOWN Millennium Cohort Study team
Sep 28, 2017·The Journal of Nervous and Mental Disease·Dolores VojvodaRobert A Rosenheck
Jun 23, 2018·Current Psychiatry Reports·Peter J ColvonenSonya B Norman
Dec 2, 2020·Journal of American College Health : J of ACH·S E CusackA B Amstadter
Dec 31, 2020·International Journal of Environmental Research and Public Health·Jessica R WatrousMichael R Galarneau
Nov 24, 2020·Child and Adolescent Psychiatric Clinics of North America·Veronica FellmanSuchet Rao
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Aug 21, 2021·Contemporary Clinical Trials·John H KrystalUNKNOWN CSP 2016 Study Team

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