Sleep disturbances and dementia risk: A multicenter study

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Shireen SindiMiia Kivipelto

Abstract

Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Sleep disturbances were assessed in three population-based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late-life baseline analyses (3-10 years follow-up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow-up) (N = 1407). Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02-1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08-3.49) were associated with a higher dementia risk. Late-life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87-8.48). Midlife insomnia and late-life terminal insomnia or long sleep duration were associated with a higher late-life dementia risk.

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Citations

Aug 2, 2019·Current Neuropharmacology·Eric Murillo-RodríguezPablo Torterolo
Sep 22, 2020·JAMA Network Open·Yanjun MaWuxiang Xie
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Oct 13, 2019·Journal of the American Medical Directors Association·Li FanChenkai Wu
Jul 27, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Andrée-Ann BarilMatthew P Pase

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