Sleep duration and endometrial cancer risk

Cancer Causes & Control : CCC
Susan R SturgeonKatherine W Reeves

Abstract

Recent data indicate that night shift work is associated with increased endometrial cancer risk, perhaps through a pathway involving lower melatonin production. Melatonin is an antiestrogenic hormone, with production in a circadian pattern that is dependent on presence of dark at night. Sleep duration is positively associated with melatonin production and may be an indicator of melatonin levels in epidemiologic studies. We evaluated associations between self-reported sleep duration and endometrial cancer risk using publicly available prospective data on 48,725 participants in the Women's Health Initiative Observational Study, among whom 452 adjudicated incident cases of endometrial cancer were diagnosed over approximately 7.5 years of follow-up. Sleep duration was self-reported at baseline. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for endometrial cancer risk with adjustment for potential confounders. Most women reported sleeping ≤ 6 (33.3%) or 7 (38.5%) h each night; fewer reported sleeping 8 (23.4%) or ≥ 9 (4.8%) h each night. In adjusted analyses, there was an indication of reduced risk associated with longer sleep duration, though no statistically significa...Continue Reading

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Citations

Jul 19, 2012·Cancer Causes & Control : CCC·Thomas C Erren
Oct 10, 2014·The Cancer Journal·Mellar P Davis, Harold W Goforth
Jan 18, 2013·American Journal of Epidemiology·Jennifer GirschikLin Fritschi
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Hao ZhaoShao-Fa Nie
May 1, 2015·Cancer Causes & Control : CCC·Susan HurleyPeggy Reynolds
Sep 10, 2016·PloS One·Fangyi GuNeil E Caporaso
Mar 31, 2017·British Journal of Cancer·Claudia Trudel-FitzgeraldEva S Schernhammer
Apr 8, 2017·Nutrients·Xiao MengHua-Bin Li
Sep 17, 2013·International Journal of Cancer. Journal International Du Cancer·Yingyi QinJia He
Dec 20, 2018·Sleep·Jessica McNeilDarren R Brenner
Jan 5, 2013·British Journal of Cancer·L JiaoH B El-Serag
Sep 29, 2019·Current Drug Targets·Parisa Maleki DanaZatollah Asemi
Sep 1, 2016·Animal Cognition·Kinsey H PhilipsEmilie C Snell-Rood
Apr 18, 2021·Molecular and Cellular Biochemistry·Maryam EzzatiRaziyeh Kheirjou
Apr 28, 2021·Chronobiology International·Julie Von BehrenPeggy Reynolds

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