Sleep duration is associated with dyslipidemia in patients with bipolar disorder in clinical remission.

Journal of Affective Disorders
I SorecaDavid Kupfer

Abstract

The pathways to increased cardiovascular risk in bipolar disorder include health behaviors, psychosocial stress and long-term medication exposure. However, the evidence that the association between cardiovascular risk factors and bipolar disorder remains significant after controlling for these co-factors suggests that additional important risk factors have yet to be identified. Our hypothesis is that disturbances in the sleep-wake cycle are an important and under-recognized pathway through which affective disorders lead to increased cardiovascular risk. In patients with bipolar disorder type 1 in clinical remission, we: 1) explored whether sleep disturbance predicted the endorsement of NCEP ATP-III criteria for dyslipidemia, independent of other lifestyle factors and 2) tested the association between low HDL (NCEP-ATP III) and sleep duration measured with actigraphy over an eight-day period. Median sleep duration is significantly associated with low HDL. The risk of having low HDL increases by 1.23 with every 30 minutes of reduced sleep time. Since sleep patterns in patients with bipolar disorder are variable and irregular, it is possible that other sleep characteristics, not present during the span of our study, or the variabi...Continue Reading

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Citations

Mar 1, 2013·Chronobiology International·Isabella SorecaDavid J Kupfer
Mar 25, 2014·Journal of Affective Disorders·Pierre Alexis GeoffroyBruno Etain
Jun 9, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·C BoudebesseB Etain
Jan 1, 2015·L'Encéphale·J-A Micoulaud FranchiJ-M Azorin
Sep 25, 2016·L'Encéphale·H BrochardB Étain
Sep 28, 2016·L'Encéphale·P A GeoffroyB Etain
Nov 23, 2017·Sleep·Meredith L WallaceUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Sep 18, 2013·Current Psychiatry Reports·Rébecca RobillardIan B Hickie
Mar 7, 2017·Frontiers in Cellular Neuroscience·Yeni KimMaria C Marchetto
Mar 17, 2019·Health and Quality of Life Outcomes·Yaxuan RenYi Cheng
Jan 26, 2021·Acta Psychiatrica Scandinavica·Kody G KennedyBenjamin I Goldstein
Mar 11, 2021·Neuroscience and Biobehavioral Reviews·Joanne S CarpenterIan B Hickie

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