Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Shahmir SohailAndrew S P Lim

Abstract

Patients with Parkinson's disease (PD) frequently experience disrupted sleep, and several sleep abnormalities are associated with an increased risk of incident PD. However, there are few data concerning the relationship between objectively quantified sleep disruption and the cardinal histopathological features of PD, especially in individuals without clinical PD. We studied 269 older adults without PD who had participated in the Rush Memory and Aging Project and undergone uniform structured neuropathologic evaluations upon death. Sleep fragmentation was measured using actigraphy. Logistic regression models examined the associations of sleep fragmentation proximate to death with the burden of Lewy body pathology and substantia nigra neuron loss. Greater sleep fragmentation was associated with the presence of Lewy body pathology (odds ratio 1.40; 95% confidence interval 1.05-1.86; P = .02) and substantia nigra neuron loss (odds ratio 1.43; 95% confidence interval 1.10-1.88; P = .008) and a higher odds of a pathological diagnosis of PD (odds ratio 2.04; 95% confidence interval 1.34-3.16; P = .0009). These associations were independent of motor features of parkinsonism, demographic characteristics, and a wide range of medical co-mo...Continue Reading

References

May 8, 1978·Journal of Theoretical Biology·P G Sokolove, W N Bushell
Jan 1, 1983·The American Journal of Psychiatry·R E Roberts, S W Vernon
Aug 15, 1996·Biological Psychiatry·E J van SomerenD F Swaab
Dec 1, 1996·Neurology·P Jenner, C W Olanow
Apr 28, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D A BennettR S Wilson
Apr 10, 2002·Neurology·I ArnulfY Agid
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Jan 23, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Pudukode R KrishnanMadhuri Behari
Apr 1, 2003·Annals of Neurology·Peter Jenner
Sep 1, 2004·Cell and Tissue Research·Heiko BraakKelly Del Tredici
Dec 24, 2005·Annals of Neurology·Julie A SchneiderDavid A Bennett
Nov 14, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·M D GjerstadJ P Larsen
Mar 1, 2007·Psychosomatic Medicine·Robert S WilsonDavid A Bennett
May 11, 2007·Brain : a Journal of Neurology·Thomas C ThannickalJerome M Siegel
Mar 16, 2011·American Journal of Epidemiology·Jianjun GaoHonglei Chen
Aug 13, 2011·Neurology·Friederike Sixel-DöringClaudia Trenkwalder
Aug 27, 2011·American Journal of Respiratory and Critical Care Medicine·Deepti NairDavid Gozal
Sep 3, 2011·Stroke; a Journal of Cerebral Circulation·Aron S BuchmanJulie A Schneider
Mar 1, 2012·Annals of Neurology·Aron S BuchmanDavid A Bennett
Apr 5, 2012·Current Alzheimer Research·David A BennettRobert S Wilson
Nov 28, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·David P BreenRoger A Barker
Jan 25, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Aron S BuchmanDavid A Bennett
Oct 19, 2013·Science·Lulu XieMaiken Nedergaard
Jan 29, 2014·Nature Reviews. Neurology·He-Jin LeeSeung-Jae Lee
Feb 26, 2014·JAMA Neurology·Aleksandar VidenovicPhyllis C Zee
May 7, 2015·Oxidative Medicine and Cellular Longevity·Gabriel VillafuerteOscar Arias-Carrión
Aug 13, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaThomas G Beach
Jan 16, 2016·Stroke; a Journal of Cerebral Circulation·Andrew S P LimAron S Buchman

❮ Previous
Next ❯

Citations

Jun 6, 2018·Journal of Alzheimer's Disease : JAD·David A BennettJulie A Schneider
May 1, 2019·Brain : a Journal of Neurology·Thom S LysenM Arfan Ikram
Dec 7, 2019·Journal of Neurology·Lindsay H M Keir, David P Breen
Jun 7, 2018·International Journal of Epidemiology·Yue LengKristine Yaffe
Jan 5, 2019·Journal of Neurology·Claudio LiguoriMariangela Pierantozzi
Dec 4, 2019·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Eiko N Minakawa
Mar 20, 2019·Annals of Neurology·Simon J SchreinerChristian R Baumann
Sep 22, 2020·Chest·Annie C LajoieMarta Kaminska
Nov 19, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kenneth RockwoodLindsay M K Wallace
Oct 24, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Manuel Montero-OdassoRichard Camicioli
Sep 30, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Beatrice OrsoDario Arnaldi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.