Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People

Stroke; a Journal of Cerebral Circulation
Andrew S P LimAron S Buchman

Abstract

Although several forms of sleep disruption are associated with stroke, few studies have examined the relationship between sleep and histopathologic measures of cerebrovascular disease. We tested the hypothesis that greater sleep fragmentation is associated with a higher burden of cerebral vessel and infarct pathology at autopsy. We used ordinal logistic regression models to relate sleep fragmentation measured by actigraphy to the severity of arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy, and the number of macroscopic and microscopic infarcts assessed by structured brain autopsy in 315 participants from the Rush Memory and Aging Project. Greater sleep fragmentation was associated with more severe arteriolosclerosis (odds ratio, 1.27; 95% confidence interval, 1.02-1.59; P=0.03 per 1 SD greater sleep fragmentation) and more subcortical macroscopic infarcts (odds ratio, 1.31; 95% confidence interval, 1.01-1.68; P=0.04). These associations were independent of established cardiovascular risk factors and diseases, and several medical comorbidities. Sleep fragmentation is associated with arteriolosclerosis and subcortical infarcts in older adults.

Associated Clinical Trials

Jan 25, 2018·Dr. Andrew Lim

References

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Citations

Mar 20, 2016·Cellular and Molecular Neurobiology·Joel RamirezSandra E Black
May 23, 2016·Journal of Neuropathology and Experimental Neurology·Peter T NelsonEseosa T Ighodaro
Sep 1, 2017·Geriatrics & Gerontology International·Joji InamasuMasashi Nakatsukasa
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Jun 6, 2018·Journal of Alzheimer's Disease : JAD·David A BennettJulie A Schneider
Dec 1, 2017·Journal of Clinical Gastroenterology·Parth J ParekhDavid A Johnson
Dec 6, 2017·Journal of Clinical Gastroenterology·Parth J ParekhDavid A Johnson
Oct 31, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Shahmir SohailAndrew S P Lim
Nov 27, 2018·Frontiers in Aging Neuroscience·Katie PalmerAnnalena Venneri
Aug 5, 2017·Frontiers in Aging Neuroscience·Nicholas W DeKorverStephen J Bonasera
Oct 25, 2020·Acta Neuropathologica·Brittney L BlevinsPeter T Nelson
Jan 15, 2021·Mechanisms of Ageing and Development·Claudio LiguoriCinzia Costa
Oct 24, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Manuel Montero-OdassoRichard Camicioli
Apr 28, 2021·Stroke; a Journal of Cerebral Circulation·Rosa SommerAndrew S P Lim
Jul 31, 2021·NeuroImage. Clinical·Nazanin MakkinejadKonstantinos Arfanakis

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