Sleep function(s) and cerebral metabolism

Behavioural Brain Research
P Maquet

Abstract

The function(s) of sleep would probably be better understood if the metabolic processes taking place within the central nervous system (CNS) during sleep were known in greater detail. The general pattern of the energy requirements of the brain during sleep is now outlined. Brain energy metabolism dramatically decreases during slow wave sleep (SWS) whereas, during rapid eye movement sleep (REMS), the level of metabolism is similar to that of wakefulness. However, these modifications of the energy metabolism, in good agreement with intracerebral recordings of neuronal firing, do not help in identifying the function(s) of sleep, since they are in line with several theories of sleep function(s) (protection, energy conservation, brain cooling, tissue restitution). On the other hand, several studies of brain basal metabolism suggest an enhanced synthesis of macromolecules such as nucleic acids and proteins in the brain during sleep. However, up to now, these data remain scarce and controversial. As a consequence, the research in the field of the brain metabolism during sleep has now come to a turning point, since the confirmation of sizeable cerebral anabolic processes would provide an outstanding argument in favour of the restorativ...Continue Reading

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