Sleep, immunity, and circadian clocks: a mechanistic model

Gerontology
T BollingerW Solbach

Abstract

The lack of sufficient amounts of sleep is a hallmark of modern living, and it is commonly perceived that in the long run this makes us sick. An increasing amount of scientific data indicate that sleep deprivation has detrimental effects on immune function. Conversely, immune responses feedback on sleep phase and architecture. Several studies have investigated the impact of short-term sleep deprivation on different immune parameters, whereas only a few studies have addressed the influence of sleep restriction on the immune system. In many cases, sleep deprivation and restriction impair immune responses by disrupting circadian rhythms at the level of immune cells, which might be a consequence of disrupted endocrine and physiological circadian rhythms. Little is known about the mechanisms underlying the circadian regulation of immunity, but recent studies have suggested that local as well as central circadian clocks drive the rhythms of immune function. In this review, we present a mechanistic model which proposes that sleep (through soluble factors and body temperature) primes immune cells on the one hand, and, on the other hand, provides a timing signal for hematopoietic circadian clocks. We hypothesize that chronic sleep disru...Continue Reading

Citations

Jun 2, 2012·Journal of Neural Transmission·Harris Eyre, Bernhard T Baune
Dec 12, 2012·The British Journal of Nutrition·Béatrice GleizePatrick Borel
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rajesh NarasimamurthyInder M Verma
Dec 12, 2012·American Journal of Epidemiology·Juhua LuoKaren L Margolis
Jul 27, 2012·American Journal of Physiology. Renal Physiology·Jacob RichardsMichelle L Gumz
Jan 5, 2012·PloS One·Thomas BollingerWerner Solbach
Jan 11, 2014·World Journal of Gastroenterology : WJG·Tauseef AliWilliam C Orr
Jan 5, 2012·Sleep·Mihai C Teodorescu, Mihaela Teodorescu
Nov 23, 2013·Current Rheumatology Reports·Laura-Isabel ArranzCayetano Alegre
Apr 2, 2014·BMC Public Health·Maria K LuojusJussi Kauhanen
Jul 16, 2014·Heart & Lung : the Journal of Critical Care·Melissa P KnauertMargaret A Pisani
Aug 27, 2014·Sleep Medicine·Fátima Pérez de HerediaUNKNOWN HELENA Study Group
Jul 17, 2012·Journal of Clinical Immunology·Sarah KirschUrban Sester
Jul 16, 2014·Inflammatory Bowel Diseases·Tauseef Ali, William C Orr
Oct 31, 2015·Journal of Cellular Physiology·Lisandro LungatoVânia D'Almeida
May 24, 2013·Chronobiology International·Nicolas CermakianGianluigi Mazzoccoli
Sep 17, 2015·Journal of Clinical Nursing·Linda GellerstedtMonica Rydell Karlsson
Oct 27, 2012·Neurologic Clinics·Charlene E GamaldoJustin C McArthur
Dec 17, 2014·Neuroscience Letters·Carina ZuppaMoisés Evandro Bauer
Jan 16, 2013·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Ernest R VinaTammy O Utset
Dec 14, 2011·Annals of Neurology·Anne-Louise Ponsonby, Robyn M Lucas
Jun 12, 2013·Acta Physiologica·T Porkka-HeiskanenH-K Wigren
Oct 19, 2011·Annals of Neurology·Anna Karin HedströmLars Alfredsson
Sep 12, 2013·Geriatrics & Gerontology International·Patrícia Vidal de Negreiros NóbregaJohn Fontenele Araújo
Aug 21, 2015·Journal of the History of the Neurosciences·Aleksandar DamjanovicNikola N Trajanovic
Oct 29, 2015·Current Stem Cell Reports·David E Muench, H Leighton Grimes
May 1, 2015·Malaria Journal·Lisandro LungatoVânia D'Almeida
May 12, 2016·Pharmacological Reports : PR·Aleksandra Sobolewska-WłodarczykMaria Wiśniewska-Jarosińska
Feb 24, 2015·Multiple Sclerosis : Clinical and Laboratory Research·A K HedströmL Alfredsson
Feb 28, 2017·Journal of Developmental and Behavioral Pediatrics : JDBP·Hui-Chin Hsu
Jun 1, 2015·Irish Journal of Psychological Medicine·G Stores
Jun 19, 2019·Annals of Work Exposures and Health·Nitt HanprathetWiroj Jiamjarasrangsi
Jul 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jacob RichardsMichelle L Gumz
Apr 3, 2012·Critical Care Nurse·Freda DeKeyser Ganz
Oct 25, 2013·American Journal of Physiology. Renal Physiology·Jacob RichardsMichelle L Gumz
Aug 29, 2018·Journal of Clinical Medicine·Stephanie BalikjiJoris C Verster
Mar 6, 2019·Journal of Oral Microbiology·Brij BhushanL Ganju

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