Sleep Impairment and Psychological Distress among Patients with Inflammatory Bowel Disease-beyond the Obvious

Journal of Clinical Medicine
Georgiana-Emmanuela Gîlc-BlanariuManuela Ciocoiu

Abstract

A healthy sleep-wake cycle is fundamental for regulating immune function. Sleepiness and fatigue are often manifestations of chronic inflammatory disorders, such as inflammatory bowel disease (IBD), potentially influencing the course of the disease. Our aim was to characterize sleep impairment in patients with IBD and to identify potential associated factors. We conducted a single-center prospective case control study including IBD patients and healthy controls. We evaluated clinical and biochemical parameters, sleep impairment through Pittsburgh Sleep Quality Index (PSQI) and anxiety and depression through Hospital Anxiety and Depression Scale (HADS) questionnaires. In total, 110 patients with IBD and 66 healthy controls were included. Patients with IBD had a significantly altered sleep quality compared to the control group (p < 0.001), with sleep impairment also occurring for patients in remission (median PSQI = 7), but without significant differences between ulcerative colitis and Crohn's disease. However, PSQI was correlated with disease activity scores only for ulcerative colitis and not for Crohn's disease. Among patients with increased PSQI, only 30.19% used sleep medication. Sleep impairment was significantly correlated...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Ziba RanjbaranAli Keshavarzian
Aug 11, 2011·Inflammatory Bowel Diseases·Lesley A GraffCharles N Bernstein
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwin N AnanthakrishnanMichael D Kappelman
May 2, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwin N AnanthakrishnanAndrew T Chan
Jul 16, 2014·Inflammatory Bowel Diseases·Tauseef Ali, William C Orr
Nov 19, 2015·Frontiers in Immunology·Italia Loddo, Claudio Romano
Nov 1, 2016·Digestive Diseases and Sciences·Betsy W StevensAshwin N Ananthakrishnan
Mar 22, 2018·Inflammatory Bowel Diseases·Simon R KnowlesAntonina Mikocka-Walus
May 31, 2018·PeerJ·Vanessa IbáñezOmar Cauli
Aug 31, 2018·International Journal of Behavioral Medicine·Megan M HoodAli Keshavarzian
Oct 4, 2018·Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society·A Sobolewska-WlodarczykJ Fichna
Nov 6, 2018·Inflammatory Bowel Diseases·Taha Qazi, Francis A Farraye
Sep 17, 2019·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Farzaneh HabibiMohammad Hassan Emami

❮ Previous
Next ❯

Citations

Jul 3, 2021·Sleep Medicine Reviews·Andrea BallesioCaterina Lombardo

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
A Sobolewska-WlodarczykJakub Fichna
Journal of Clinical Medicine
Marcin SochalPiotr Białasiewicz
Journal of Gastroenterology and Hepatology
Ziba RanjbaranAli Keshavarzian
© 2021 Meta ULC. All rights reserved