PMID: 9163548Apr 25, 1997Paper

Sleep in rats rendered chronically hyperprolactinemic with anterior pituitary grafts

Brain Research
F ObálJames M Krueger

Abstract

A hyperprolactinemic rat model [rats bearing anterior pituitary grafts under the capsule of the kidney (AP-grafted rats)] was used to study sleep-wake activity and cortical brain temperature (T(crt)). Fisher 344 male rats (n = 24) were implanted with anterior pituitaries from rat pups; the control rats (n = 12) were sham-operated. Sleep-wake activity and T(crt) were recorded for 2 days between weeks 3 and 7 after surgery. The hyperprolactinemic state of the rats was confirmed by plasma prolactin (PRL) assays on week 7 and by determination of PRL mRNA levels in the anterior pituitary of the AP-grafted rats. Neither growth hormone plasma concentration nor pituitary mRNA levels were affected by the pituitary grafts. Duration of non-rapid eye movement sleep (NREMS) was slightly enhanced in the AP-grafted rats. A large increase in rapid eye movement sleep (REMS) during the 12-h light period was the major effect of the implantation of the extra pituitaries. Both the duration and the frequency of the REMS episodes increased and persisted for weeks 4-7 post-implantation. The nocturnal states of vigilance, T(crt), and intensity of NREMS (EEG slow wave activity) were not altered. The results clearly indicate that the enhancements in REMS...Continue Reading

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Citations

Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·R M FrieboesA Steiger
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I HajduC D Rollo
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·James M. KruegerFerenc Obál
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B BodosiJ M Krueger
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Feb 12, 2004·American Journal of Physiology. Endocrinology and Metabolism·Carol A Everson, William R Crowley
Jul 25, 2012·Annals of the New York Academy of Sciences·Beatriz Gómez-GonzálezJavier Velázquez-Moctezuma
Sep 1, 2006·Expert Review of Endocrinology & Metabolism·Axel Steiger
Mar 5, 2003·Brain, Behavior, and Immunity·James M KruegerFerenc Obál

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