Sleep induction and temperature lowering by medial preoptic alpha(1) adrenergic receptors

Physiology & Behavior
Ramalingam VetrivelanVelayudhan Mohan Kumar

Abstract

Changes in sleep-wakefulness (S-W) and body temperature (T(b)) on administration of alpha(1) agonist (methoxamine) and antagonist (prazosin) into the medial preoptic area (mPOA) were studied in rats. Presynaptic catecholaminergic terminals of the mPOA were destroyed by injecting 6-hydroxydopamine at the ventral noradrenergic bundle (VNA), before administration of the drugs. Microinjection of 0.05 microg methoxamine induced sleep, though 0.1 microg prazosin produced no change in S-W. On the other hand, in normal rats, the same dose of methoxamine produced no change, while prazosin produced arousal. Denervation hypersensitivity may be responsible for the appearance of hypnogenic response on methoxamine administration, in the VNA-lesioned rats. The VNA-lesioned animals (before administration of any drug) had higher pre-injection values of wake period than the normal rats. A reduction in the tonic activity of noradrenergic fibers to the mPOA, and resulting reduced activity of alpha(1) receptors, may be responsible for increased wake period in the VNA-lesioned rats. The action of prazosin was probably abolished in the absence of tonic activity of alpha(1) receptor in the VNA-lesioned rats. Reduction and increase in T(b) produced by ...Continue Reading

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Citations

Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Hadine JoffeJanet E Hall
May 4, 2017·Therapeutic Hypothermia and Temperature Management·Rishabh Charan Choudhary, Xiaofeng Jia
Oct 10, 2018·Nature Communications·Daniel KroegerRamalingam Vetrivelan
Aug 26, 2006·Neurochemical Research·Velayudhan Mohan KumarHruda Nanda Mallick

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