PMID: 8950279Jan 1, 1996Paper

Sleep induction by microinjection of pentobarbital into the medial preoptic area in rats

Life Sciences
W B Mendelson

Abstract

In a previous study we have shown that microinjection of the benzodiazepine hypnotic triazolam into the medial preoptic area increases sleep in rats. In order to determine whether this effect is specific to benzodiazepines, or whether it occurs with hypnotic medications from other pharmacologic classes, we have microinjected pentobarbital (1 and 100 micrograms) and vehicle in random sequence into rats and performed two hour sleep studies in the daytime with the lights on. Both doses significantly decreased sleep latency and increased nonREM and total sleep. The amount of REM sleep, REM latency, and intermittent waking time were not significantly altered. These data are consistent with the hypothesis that the medial preoptic area may be involved in sleep induction by both benzodiazepine and barbiturate hypnotic medications.

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Citations

Jun 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N AnzawaA Matsuki
Aug 26, 1998·Pharmacology, Biochemistry, and Behavior·W B Mendelson
Apr 22, 2008·Nature Reviews. Neuroscience·Nicholas P Franks
Feb 12, 2008·The International Journal of Neuropsychopharmacology·Eszter KirillyGyorgy Bagdy
Mar 13, 2008·The Journal of Comparative Neurology·K ReinerM Devor
Apr 3, 2008·The Journal of Comparative Neurology·Jun LuClifford B Saper
Jul 10, 2002·Obesity Research·Roland RosmondPer Björntorp

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