Abstract
Patients with sickle cell disease (SCD) regularly experience abnormal sleep, characterized by frequent arousals and reduced total sleep time. However, obstructive sleep apnea syndrome (OSAS) is a common comorbidity of SCD, making it unclear whether the disease per se is impacting sleep, or sleep disruption is secondary to the presence of OSAS. Thus, we assessed sleep, independent of OSAS, using a mouse model of SCD. Sleep was compared between 10-to-12-week-old Townes knockout-transgenic mice with the sickle cell phenotype SS (n = 6) and Townes mice with sickle cell trait AS (n = 6; control). The mice underwent chronic polysomnographic electrode implantation (4EEG/2EMG) to assess sleep architecture. The SS mice had significantly lower hemoglobin concentration compared to control AS mice (7.3 ± 1.3 vs. 12.9 ± 1.7 g/dL; p < 0.01), consistent with the expected SCD phenotype. SS mice exhibited significantly decreased total NREM sleep time (45.0 ± 0.7 vs. 53.0 ± 1.3% 24 h sleep time; p < 0.01), but no change in total REM sleep time compared to the AS mice. The SS mice took longer to resume sleep after a wake period compared to the AS mice (3.2 ± 0.3 min vs. 1.9 ± 0.2 min; p < 0.05). Unexpectedly, SS mice experienced fewer arousals co...Continue Reading
References
Feb 1, 1994·Sleep·J H BeningtonH C Heller
Nov 5, 1997·Science·T M RyanT M Townes
Nov 5, 1997·Science·C PásztyE M Rubin
Sep 27, 2003·American Journal of Respiratory and Critical Care Medicine·Arnon E RubinChristopher P O'Donnell
May 29, 2004·Sleep·Sigrid C VeaseyPolina Fenik
Nov 25, 2004·Hematology·George R BuchananMartin H Steinberg
Dec 18, 2004·Blood Reviews·Duane Robina Bonds
Nov 29, 2005·Sleep Medicine·Vsevolod Y PolotskyChristopher P O'Donnell
Sep 26, 2006·Pediatric Pulmonology·Ashok B RajHarvey L Edmonds
Nov 7, 2006·Blood Reviews·Gregory J KatoMartin H Steinberg
Nov 14, 2006·Sleep Medicine·Terry DeanChristopher J Earley
Apr 3, 2007·Diabetes·Laura C AlonsoAdolfo Garcia-Ocaña
Oct 2, 2007·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Lisliê Capoulade Nogueira Arrais de Souza, Carlos Alberto de Assis Viegas
Nov 6, 2010·Maternal & Child Nutrition·Aida Malek MahdaviAbdolrasool Safaiyan
Apr 13, 2011·PloS One·Samit GhoshSolomon F Ofori-Acquah
Nov 26, 2011·Journal of the International Neuropsychological Society : JINS·Matthew J HollocksMichelle de Haan
Aug 21, 2012·The Journal of Urology·Marina RoizenblattSuely Roizenblatt
Aug 23, 2012·The Journal of Urology·Gloria C LehmannMichael R DeBaun
Feb 6, 2013·Pediatric Blood & Cancer·Paul FinchJane S Hankins
Jun 1, 2013·Journal of Applied Physiology·Eric M DavisChristopher P O'Donnell
Jul 16, 2014·Pediatrics·Carol L RosenFenella J Kirkham
Jan 18, 2017·JCI Insight·Margaret F BennewitzPrithu Sundd
Citations
Jan 11, 2020·Preparative Biochemistry & Biotechnology·Fatih ErciEmrah Torlak
Dec 11, 2019·Blood Advances·Katherine C WoodAdam C Straub
Dec 4, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Heidi M SchmidtAdam C Straub
May 28, 2021·Redox Biology·Ammar Saadoon AlishlashSadis Matalon