Sleep-Promoting Effects and Possible Mechanisms of Action Associated with a Standardized Rice Bran Supplement

Nutrients
Hyejin YangSuengmok Cho

Abstract

Natural sleep aids are becoming more popular due to the widespread occurrence of sleep disorders. The objective of this study was to assess the sleep-promoting effects of rice bran-a product that is considered as a functional ingredient. To evaluate the sleep-promoting effects of a standardized rice bran supplement (RBS), we employed a pentobarbital-induced sleep test and conducted analyses of sleep architecture. In addition, the effect of RBS on a caffeine-induced sleep disturbance was investigated. Oral administration of RBS (500 and 1000 mg/kg) produced a significant decrease in sleep latency and increase in sleep duration in pentobarbital-induced sleep in mice. Moreover, both RBS (1000 mg/kg) and doxepin hydrochloride (histamine H₁ receptor antagonist, 30 mg/kg) counteracted a caffeine-induced sleep disturbance in mice. In terms of sleep phases, RBS (500 mg/kg) promoted non-rapid eye movement sleep for the first 3 h following its administration. Lastly, we unveiled a possible mechanism for RBS action as the hypnotic effect of RBS was blocked by a histamine H₁ receptor agonist. The present study revealed sleep-promoting effects of RBS using various animal assays. Such effects seem to be mediated through the histaminergic sys...Continue Reading

References

Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·S W Wurts, D M Edgar
Jan 18, 2003·Sleep Medicine Reviews·Charlotte GyllenhaalTom Gochenour
Jul 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hans-Peter LandoltPeter Achermann
Aug 11, 2004·Sleep Medicine·Thomas Roth, Christopher Drake
Jun 21, 2005·Nature Neuroscience·Zhi-Li HuangOsamu Hayaishi
Feb 2, 2006·American Journal of Obstetrics and Gynecology·Nancy E Lane
Dec 13, 2006·Clinical Therapeutics·Nancy L Borja, Karen L Daniel
Feb 20, 2007·CNS & Neurological Disorders Drug Targets·A J Barbier, M J Bradbury
Jan 29, 2008·Expert Opinion on Pharmacotherapy·Abid BhatAli A El Solh
Nov 6, 2008·Nature Reviews. Neuroscience·James M KruegerJaak Panksepp
Feb 12, 2009·Nature Reviews. Neuroscience·Luca Imeri, Mark R Opp
May 12, 2009·Neuroscience and Biobehavioral Reviews·Florent G RevelJean-Luc Moreau
Sep 17, 2009·Journal of Clinical Pharmacy and Therapeutics·L-C ChenC-H Shao
Mar 30, 2010·Journal of Ethnopharmacology·Jie-Xin CaoYu-Ying Zhao
Oct 23, 2010·Sleep Medicine Reviews·Jerome Sarris, Gerard J Byrne
Nov 1, 2011·Molecular Nutrition & Food Research·Mika MasakiYoshihiro Urade
May 29, 2012·CNS Neuroscience & Therapeutics·Zheng LiuWei-Min Qu
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Mian Kamran SharifSaima Hafiz Khan
Apr 1, 2017·Nature and Science of Sleep·Kate RomeroMatt T Bianchi

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