Sleep protects against chemotherapy induced emesis

Cancer
L Domínguez-OrtegaE Díaz-Gállego

Abstract

We present a clinical trial to assess the hypothesis that chemotherapy related emesis is reduced when drugs delivered while the patient is sleeping. Adults without previous sleep disturbances of vomit inducing conditions who were going to receive their first courses of 100 mg/m2 cisplatin were included. We reduced antiemetic prophylaxis consisting of ondansetron and dexamethasone in subsequent groups of patients. Twenty-one individuals were needed to decrease the antiemetic prophylaxis to zero. Significant vomiting was observed only when prophylaxis was abolished but not in previous steps employing negligible doses of prophylaxis. Our data show that when cisplatin is administered during sleep, the reduction of antiemetic prophylaxis id not followed by the expected increase in emetic toxicity. This antiemetic property of sleep is, as far as we know, unassessed in a controlled way. Further study of the clinical utility of this method in the prevention of chemotherapy related emesis is indicated.

References

Apr 1, 1975·Electroencephalography and Clinical Neurophysiology·I Lichter, R C Muir
Jul 1, 1978·Gut·R F McCloyJ H Baron
Jan 1, 1982·Psychophysiology·W E WhiteheadM M Schuster
Feb 1, 1956·Journal of Dental Research·L H SCHNEYERR W GILMORE
May 1, 1958·The American Journal of Physiology·S C WANGH I CHINN

❮ Previous
Next ❯

Citations

Jan 5, 2002·Chronobiology International·M KobayashiE Kobayashi
Feb 11, 2000·Psycho-oncology·L TroyD Thomson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.