Sleep protects excitatory cortical circuits against oxidative damage

Medical Hypotheses
Georg Schulze

Abstract

Activity in excitatory cortical pathways increases the oxidative metabolism of the brain and the risk of oxidative damage. Oxyradicals formed during periods of activity are mopped up by neural pools of nuclear factor kappa-B resulting in their activation and translocation to cell nuclei. During waking hours, glucocorticoids inhibit transactivation by nuclear factor kappa-B, increase central norepinephrine release, and elevate expression of prostaglandin D2. The build-up of nuclear factor kappa-B and prostaglandin D2 produces sleep pressures leading to sleep onset, normally gated by circadian melatonin release. During slow wave sleep nuclear factor kappa-B induces transcription of synaptogenic and antioxidant products and synaptic remodeling follows. Synaptically remodeled neural circuits have modified conductivity patterns and timescales and need to be resynchronized with existing unmodified neural circuits. The resynchronization process, mediated by theta rhythm, occurs during rapid eye movement sleep and is orchestrated from pontine centers. Resynchronization of remodeled neural circuits produces dreams. The waking state results upon successful resynchronization. Rapid eye movement sleep deprivation results in a lack of resyn...Continue Reading

References

Jun 1, 1996·Brain Research. Molecular Brain Research·P J MebergA Routtenberg
Mar 1, 1997·Journal of Neurosurgery·S HolminT Mathiesen
Jul 2, 1999·Journal of Sleep Research·J M KruegerJ Fang
Feb 9, 2000·Frontiers in Neuroendocrinology·N A Compagnone, S H Mellon
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Z GuJ R Perez-Polo
Jul 8, 2000·Journal of Biological Rhythms·E Van PraagR Bachofen
Mar 10, 2001·Current Opinion in Neurobiology·C Scharff
Aug 8, 2001·Immunology and Cell Biology·I M Adcock, G Caramori
Feb 15, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Osamu Hayaishi, Yoshihiro Urade
Jul 12, 2002·Cell and Tissue Research·Charlotte von GallDavid R Weaver
Jul 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Arien J SmithFahmeed Hyder
Nov 22, 2002·Journal of Neuroscience Research·Philip K Liu, Tarun Arora
May 24, 2003·Consciousness and Cognition·Michael Schredl, Friedrich Hofmann
Jun 10, 1960·Science·W DEMENT
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Apr 29, 1966·Science·H P RoffwargW C Dement

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Citations

Feb 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryce A ManderPhyllis C Zee
Jan 23, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Beatrice A Golomb, Marcella A Evans
Jan 7, 2009·Journal of Neuroscience Research·Corinne J Montes-RodríguezOscar Prospéro-García
Aug 1, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Regina H SilvaRoberto Frussa-Filho
Oct 26, 2005·Life Sciences·Martha A Sánchez-RodríguezVíctor Manuel Mendoza-Núñez

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