Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study

Sleep Science
Melinda L JacksonDorothy Bruck

Abstract

Chronic Fatigue Syndrome (CFS) is a multisystem illness, which may be associated with imbalances in gut microbiota. This study builds on recent evidence that sleep may be influenced by gut microbiota, by assessing whether changes to microbiota in a clinical population known to have both poor sleep and high rates of colonization with gram-positive faecal Streptococcus, can improve sleep. Twenty-one CFS participants completed a 22- day open label trial. Faecal microbiota analysis was performed at baseline and at the end of the trial. Participants were administered erythromycin 400 mg b.d. for 6 days. Actigraphy and questionnaires were used to monitor sleep, symptoms and mood. Changes in patients who showed a clinically significant change in faecal Streptococcus after treatment (responders; defined as post-therapy distribution<6%) were compared to participants who did not respond to treatment. In the seven responders, there was a significant increase in actigraphic total sleep time (p=0.028) from baseline to follow up, compared with non-responders. Improved vigour scores were associated with a lower Streptococcus count (ρ=-0.90, p=0.037). For both the responders and the whole group, poorer mood was associated with higher Lactobaci...Continue Reading

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Citations

Mar 29, 2019·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Leigh K Smith, Emily F Wissel
Apr 18, 2017·Current Medicinal Chemistry·Si-Si Zhou, Jian-Guo Jiang
Apr 12, 2019·Frontiers in Psychiatry·Angela MarottaMirta Fiorio
Aug 6, 2020·Frontiers in Psychiatry·Will Takakura, Mark Pimentel
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Dec 21, 2018·Frontiers in Psychiatry·Yuanyuan LiBin Zhang

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