Sleep quality, daytime sleepiness, fatigue, and quality of life in patients with multiple sclerosis treated with interferon beta-1b: results from a prospective observational cohort study

BMC Neurology
Sylvia KotterbaMarkus Schürks

Abstract

Sleep disorders and fatigue are common in multiple sclerosis (MS). The underlying causes are not fully understood, and prospective studies are lacking. Therefore, we conducted a prospective, observational cohort study investigating sleep quality, fatigue, quality of life, and comorbidities in patients with MS. Patients with relapsing-remitting MS or clinically isolated syndrome treated with interferon beta-1b were followed over two years. The primary objective was to investigate correlations between sleep quality (PSQI), fatigue (MFIS), and functional health status (SF-36). Secondary objectives were to investigate correlations of sleep quality and daytime sleepiness (ESS), depression (HADS-D), anxiety (HADS-A), pain (HSAL), and restless legs syndrome (RLS). We applied descriptive statistics, correlation and regression analyses. 139 patients were enrolled, 128 were available for full analysis. The proportion of poor sleepers (PSQI≥5) was 55.47% at the beginning and 37.70% by the end of the study (106 and 41 evaluable questionnaires, respectively). Poor sleepers performed worse in MFIS, SF-36, ESS, HADS-D, and HADS-A scores. The prevalence of patients with RLS was low (4.5%) and all were poor sleepers. Poor sleep quality was posi...Continue Reading

References

Nov 29, 2001·Multiple Sclerosis : Clinical and Laboratory Research·M P AmatoL Rossi
Mar 31, 2005·Seminars in Neurology·W Elon Fleming, Charles P Pollak
Dec 24, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Laura MendozziLuigi Pugnetti
Sep 8, 2010·Expert Review of Neurotherapeutics·Lauren B KruppChristopher Christodoulou
Feb 1, 2011·Multiple Sclerosis : Clinical and Laboratory Research·C VeauthierJ P Sieb
May 26, 2012·European Neurology·Jean-Philippe NeauGautier Bouche
Aug 24, 2012·Multiple Sclerosis : Clinical and Laboratory Research·I CôtéR J Kimoff
Oct 31, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Anna Pokryszko-DraganKatarzyna Konieczna
Nov 21, 2012·PloS One·Hanne Marie Bøe LundeLars Bø
Dec 24, 2013·Sleep Medicine·Christian Veauthier, Friedemann Paul
Dec 24, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Ruth Ann MarrieOlaf Stuve
Aug 10, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Giuseppe LanzaLuigi Ferini-Strambi

❮ Previous
Next ❯

Citations

Feb 1, 2019·Current Treatment Options in Neurology·Giorgos K SakkasMauro Manconi
Nov 8, 2018·Nutrients·Lars-Petter Jelsness-JørgensenKnut E A Lundin
Jun 4, 2019·Journal of Sleep Research·Katie L J CederbergRobert W Motl
Oct 23, 2019·Sleep·Kosuke TaniokaMauro Manconi
Mar 12, 2021·Neurological Research and Practice·Geert MayerPeter Young
Apr 3, 2021·Multiple Sclerosis and Related Disorders·Tobias MonscheinStefan Seidel
Jul 4, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Raffaele FerriMauro Manconi
Aug 15, 2021·Neurology. Neuroimmunology and Neuroinflammation·Luisa A Diaz-AriasArun Venkatesan
Aug 16, 2021·Multiple Sclerosis and Related Disorders·Katie L J CederbergRobert W Motl

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01766063

Software Mentioned

SAS
BETASLEEP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.