Sleep Regulates Glial Plasticity and Expression of the Engulfment Receptor Draper Following Neural Injury.

Current Biology : CB
Bethany A StanhopeAlex C Keene

Abstract

Chronic sleep disturbance is associated with numerous health consequences, including neurodegenerative disease and cognitive decline [1]. Neurite damage due to apoptosis, trauma, or genetic factors is a common feature of aging, and clearance of damaged neurons is essential for maintenance of brain function. In the central nervous system, damaged neurites are cleared by Wallerian degeneration, in which activated microglia and macrophages engulf damaged neurons [2]. The fruit fly Drosophila melanogaster provides a powerful model for investigating the relationship between sleep and Wallerian degeneration [3]. Several lines of evidence suggest that glia influence sleep duration, sleep-mediated neuronal homeostasis, and clearance of toxic substances during sleep, raising the possibility that glial engulfment of damaged axons is regulated by sleep [4]. To explore this possibility, we axotomized olfactory receptor neurons and measured the effects of sleep loss or gain on the clearance of damaged neurites. Mechanical and genetic sleep deprivation impaired the clearance of damaged neurites. Conversely, treatment with the sleep-promoting drug gaboxadol accelerated clearance, while genetic induction of sleep promotes Draper expression. In...Continue Reading

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Citations

Jan 13, 2021·Current Biology : CB·Orie T Shafer, Alex C Keene
Nov 26, 2020·Current Biology : CB·Lucy A L Tainton-HeapBruno van Swinderen
Feb 2, 2021·Science Advances·Bart van AlphenRavi Allada
Mar 7, 2020·Current Biology : CB·Prabhjit Singh, Jeffrey M Donlea
Feb 20, 2021·Journal of Pharmacological Sciences·Se Young Lee, Won-Suk Chung
Mar 26, 2020·Current Biology : CB·Naihua N Gong, Matthew S Kayser
Jun 10, 2021·Current Biology : CB·Jacqueline T Weiss, Jeffrey M Donlea
Jun 10, 2021·Neuroscience Bulletin·Yang Zhang, Donghong Cui

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